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Arun Singh
Faculty
Assistant Professor
Assistant Professor Basic Biomedical Sciences
Specialty
Neuroscience
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Dr. Arun Singh is an Assistant Professor in the division of BBS. He earned his Ph.D. from LMU, Munich. He completed postdoc at Emory University and worked at the University of Iowa as a staff scientist. ***Currently, Singh Lab is Looking for graduate students and research assistants! Please email Dr. Singh if you are interested in pursuing graduate studies.***
Clinical Neurosciences, Movement Disorders, Cognitive Disorders
The primary research goals of the Singh Lab are directed towards understanding the oscillatory nature of fronto-cortical region and associated network that may underlie motor and cognitive impairments in Parkinson’s disease (PD) using EEG and non-invasive neuromodulation (TMS/tES) methods. Our lab studies the relationship between motor and cognitive networks in PD patients and how cognitive impairments affect the gait and balance. Our previous articles have already shed some light on the basic questions related to the gait and balance problems in PD patients.
The objectives of our lab projects are (1) to determine the role of cortical, subcortical, and associated network-related oscillatory activities during lower-limb movements (pedaling, gait/walking) in PD patients; (2) to determine neural correlates during dual-task (lower-limb movement with the cognitive task) in PD patients with and without freezing of gait; (3) to investigate the effects of open- and advanced closed-loop neuromodulation approaches on lower-limb pedaling, gait, balance, and cognition in PD patients. To perform experiments, our lab is equipped with EEG brain recordings system, a treadmill machine with sensors to record gait and balance parameters, APDM device to record real-world gait pattern and balance, and the unweighting system to prevent participant’s fall. For neuromodulation experiments, we have TMS and tES machines.
- Postdoctoral, Neuroscience, Emory University, 2016
- Ph D, Neuroscience, Ludwig Maximilian University, 2011
- MS, Biotechnology, Devi Ahilya University, 2006
- BS, Biology, Bundelkhand University, 2002
- The effect of in-home resistance training and add-on cortical electrical stimulation on gait in PD, Seed for Success Foundation, (2023 - 2023)
- Mid-frontal/cerebellar theta activity correlates with balance dysfunction in PD, Center for Brain and Behavioral Research, (2021 - 2022)
Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.
- Bosch, Taylor, Cole, R C., Vuong, S M., Flouty, O, and Singh, Arun. Modulation of Cerebellar Oscillations with Subthalamic Stimulation in Patients with Parkinson's Disease.. Journal of Parkinson's disease, 2024. (DOI: 10.3233/JPD-240065)
- Bosch, Taylor, Espinoza, A I., and Singh, Arun. Cerebellar oscillatory dysfunction during lower-limb movement in Parkinson's disease with freezing of gait., 148334. Vol. 1808 Brain research, 2023. (DOI: 10.1016/j.brainres.2023.148334)
- Bosch, Taylor, Cole, R C., Bezchlibnyk, Y, Flouty, O, and Singh, Arun. Effects of Very Low- and High-Frequency Subthalamic Stimulation on Motor Cortical Oscillations During Rhythmic Lower-Limb Movements in Parkinson's Disease Patients., 549-561. Vol. 13, Iss. 4 Journal of Parkinson's disease, 2023. (DOI: 10.3233/JPD-225113)
- Bosch, Taylor, Groth, C, and Singh, Arun. Resting-State Low-Frequency Cerebellar Oscillations Can Be Abnormal in Parkinson's Disease., 1139-1143. Vol. 21, Iss. 6 Cerebellum (London, England), 2022. (DOI: 10.1007/s12311-021-01343-7)
- Bosch, Taylor, Espinoza, A I., Mancini, M, Horak, F B., and Singh, Arun. Functional Connectivity in Patients With Parkinson's Disease and Freezing of Gait Using Resting-State EEG and Graph Theory., 715-725. Vol. 36, Iss. 10-11 Neurorehabilitation and neural repair, 2022. (DOI: 10.1177/15459683221129282)
- Masilamoni, G J., Sinon, C G., Kochoian, B A., Singh, Arun, McRiner, A J., Leventhal, L, and Papa, S M.. Phosphodiesterase 9 inhibition prolongs the antiparkinsonian action of l-DOPA in parkinsonian non-human primates., 109060. Vol. 212 Neuropharmacology, 2022. (DOI: 10.1016/j.neuropharm.2022.109060)
- Bosch, T J., Barsainya, R, Ridder, A, KC, Santosh, and Singh, Arun. Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait., 2599-2609. Vol. 269, Iss. 5 Journal of neurology, 2022. (DOI: 10.1007/s00415-021-10843-9)
- Bosch, Taylor, Barsainya, R, Ridder, A, KC, Santosh, and Singh, Arun. Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait., 2599-2609. Vol. 269, Iss. 5 Journal of neurology, 2022. (DOI: 10.1007/s00415-021-10843-9)
- Navid, M S., Kammermeier, S, Niazi, I K., Sharma, V D., Vuong, S M., Bötzel, K, Greenlee JDW, and Singh, Arun. Cognitive task-related oscillations in human internal globus pallidus and subthalamic nucleus., 113787. Vol. 424 Behavioural brain research, 2022. (DOI: 10.1016/j.bbr.2022.113787)
- Cole, R C., Espinoza, A I., Singh, Arun, Berger, Jason, Cavanagh, J F., Wessel, J R., Greenlee, J D., and Narayanan, N S.. Novelty-induced frontal-STN networks in Parkinson's disease.. Cerebral cortex (New York, N.Y. : 1991), 2022. (DOI: 10.1093/cercor/bhac078)
- Bandyopadhyay, Ahana, Ghosh, Sourodip, Bose, Moinak, Singh, Arun, Othmani, Alice, and KC, Santosh. Alzheimer's Disease Detection Using Ensemble Learning and Artificial Neural Networks. In Recent Trends in Image Processing and Pattern Recognition - 5th International Conference, RTIP2R 2022, Kingsville, TX, USA, December 1-2, 2022, Revised Selected Papers, editors Santosh, KC; Goyal, Ayush; Aouada, Djamila; Makkar, Aaisha; Chiang, Yao-Yi; Singh, Satish Kumar, 12--21. Vol. 1704 Springer, 2022. (DOI: 10.1007/978-3-031-23599-3\_2)
- Singh, Arun, Roy, S, and KC, Santosh. Cortical oscillatory feature-based classification of Parkinson's disease with freezing gait. In MOVEMENT DISORDERS, S658--S658. Vol. 37
- Groth, C L., Singh, Arun, Zhang, Q, Berman, B D., and Narayanan, N S.. GABAergic Modulation in Movement Related Oscillatory Activity: A Review of the Effect Pharmacologically and with Aging., 48. Vol. 11 Tremor and other hyperkinetic movements (New York, N.Y.), 2021. (DOI: 10.5334/tohm.655)
- Bosch, T J., Groth, C, and Singh, Arun. Resting-State Low-Frequency Cerebellar Oscillations Can Be Abnormal in Parkinson's Disease.. Cerebellum (London, England), 2021. (DOI: 10.1007/s12311-021-01343-7)
- Bosch, Taylor, Kammermeier, S, Groth, C, Leedom, Matt, Hanson, Elizabeth, Berg-Poppe, Patti, and Singh, Arun. Cortical and Cerebellar Oscillatory Responses to Postural Instability in Parkinson's Disease., 752271. Vol. 12 Frontiers in neurology, 2021. (DOI: 10.3389/fneur.2021.752271)
- Bosch, Taylor J., Kammermeier, Stefan, Groth, Christopher, Leedom, Matt, Hanson, Elizabeth, Berg-Poppe, Patti, and Singh, Arun. Cortical and cerebellar oscillatory responses to postural instability in Parkinson’s disease, 752271. Vol. 12 Frontiers in Neuroscience, 2021. (DOI: 10.3389/fneur.2021.752271)
- Bosch, Taylor, Groth, C, Eldridge, T A., Gnimpieba, Etienne, Baugh, Lee A., and Singh, Arun. Altered Cerebellar Oscillations in Parkinson's Disease Patients during Cognitive and Motor Tasks., 185-196. Vol. 475 Neuroscience, 2021. (DOI: 10.1016/j.neuroscience.2021.08.021)
- Scholl, Jamie, Espinoza, Arturo I., Rai, Wijdan, Leedom, Matt, Baugh, Lee A., Berg-Poppe, Patti, and Singh, Arun. Relationships between freezing of gait severity and cognitive deficits in Parkinson’s disease . Brain Sciences, 2021. (DOI: https://doi.org/10.3390/brainsci11111496)
- Singh, Arun, Cole, R C., Espinoza, A I., Evans, A, Cao, S, Cavanagh, J F., and Narayanan, N S.. Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease., 14. Vol. 7, Iss. 1 NPJ Parkinson's disease, 2021. (DOI: 10.1038/s41531-021-00158-x)
- Bosch, Taylor J., Groth, Christopher, Eldridge, Tiffany A., Gnimpieba, Etienne, Baugh, Lee A., and Singh, Arun. Altered Cerebellar Oscillations in Parkinson's Disease Patients during Cognitive and Motor Tasks, 185-196. Vol. 475 NEUROSCIENCE, 2021. (DOI: 10.1016/j.neuroscience.2021.08.021)
- Singh, Arun, and Papa, S M.. Striatal oscillations in parkinsonian non-human primates.. Neuroscience, 2020. (DOI: 10.1016/j.neuroscience.2020.09.004)
- Anjum, M F., Dasgupta, S, Mudumbai, R, Singh, Arun, Cavanagh, J F., and Narayanan, N S.. Linear predictive coding distinguishes spectral EEG features of Parkinson's disease., 79-85. Vol. 79 Parkinsonism & related disorders, 2020. (DOI: 10.1016/j.parkreldis.2020.08.001)
- Espinoza, Arturo I., Scholl, Jamie L., and Singh, Arun. TMS bursts can modulate local and networks oscillations during lower-limb movement in elderly subjects. bioRxiv, 2020. (DOI: https://doi.org/10.1101/2020.08.19.257980)
- Singh, Arun, Cole, Rachel C., Espinoza, Arturo I., Brown, Darin, Cavanagh, James F., and Narayanan, Nandakumar. Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease. Clinical Neurophysiology, 2020.
- Singh, Arun, and Papa, Stella M.. Aberrant striatal oscillations after dopamine loss in parkinsonian non-human primates, 650770. bioRxiv, 2019.
- Singh, Arun, Trapp, Nicholas T., De Corte, Benjamin, Cao, Scarlett, Kingyon, Johnathon, Boes, Aaron D., and Parker, Krystal L.. Cerebellar Theta Frequency Transcranial Pulsed Stimulation Increases Frontal Theta Oscillations in Patients with Schizophrenia, 1-11. The Cerebellum, 2019.
- Singh, Arun, Cao, Scarlett, Kingyon, Johnathon, and Parker, Krystal L.. Proceedings# 32: Effects of cerebellar delta and theta frequency tACS on cognitive performance in patients with schizophrenia, e99-e100. Vol. 12, Iss. 2 Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 2019.
- Beck, Goichi, Singh, Arun, Zhang, Jie, Potts, Lisa F., Woo, Jong-Min, Park, Eun S., Mochizuki, Hideki, Mouradian, M M., and Papa, Stella M.. Role of striatal ΔFosB in l-Dopa–induced dyskinesias of parkinsonian nonhuman primates, 18664-18672. Vol. 116, Iss. 37 Proceedings of the National Academy of Sciences, 2019.
- Beck, Goichi, Singh, Arun, and Papa, Stella M.. Dysregulation of striatal projection neurons in Parkinson’s disease, 449-460. Vol. 125, Iss. 3 Journal of Neural Transmission, 2018.
- Singh, Arun, Jenkins, Meagan A., Burke, Jr, Kenneth J., Beck, Goichi, Jenkins, Andrew, Scimemi, Annalisa, Traynelis, Stephen F., and Papa, Stella M.. Glutamatergic tuning of hyperactive striatal projection neurons controls the motor response to dopamine replacement in parkinsonian primates, 941-952. Vol. 22, Iss. 4 Cell reports, 2018.
- Singh, Arun, Richardson, Sarah P., Narayanan, Nandakumar, and Cavanagh, James F.. Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease, 113-122. Vol. 117 Neuropsychologia, 2018.
- Singh, Arun. Oscillatory activity in the cortico‐basal ganglia‐thalamic neural circuits in Parkinson's disease, 2869-2878. Vol. 48, Iss. 8 European Journal of Neuroscience, 2018.
- Kammermeier, Stefan, Dietrich, Lucia, Maierbeck, Kathrin, Plate, Annika, Lorenzl, Stefan, Singh, Arun, Ahmadi, Ahmad, and Bötzel, Kai. Postural stabilization differences in Idiopathic Parkinson’s Disease and Progressive Supranuclear Palsy during self-triggered fast forward weight lifting, 743. Vol. 8 Frontiers in neurology, 2018.
- Kammermeier, Stefan, Maierbeck, Kathrin, Dietrich, Lucia, Plate, Annika, Lorenzl, Stefan, Singh, Arun, Bötzel, Kai, and Maurer, Christoph. Qualitative postural control differences in Idiopathic Parkinson’s Disease vs. Progressive Supranuclear Palsy with dynamic-on-static platform tilt, 1137-1147. Vol. 129, Iss. 6 Clinical Neurophysiology, 2018.
- Kammermeier, Stefan, Singh, Arun, and Bötzel, Kai. Intermediate latency-evoked Potentials of Multimodal cortical Vestibular areas: galvanic stimulation, 587. Vol. 8 Frontiers in neurology, 2017.
- Kammermeier, Stefan, Dietrich, Lucia, Maierbeck, Kathrin, Plate, Annika, Lorenzl, Stefan, Singh, Arun, and Bötzel, Kai. Neck Vibration Proprioceptive Postural response intact in Progressive supranuclear Palsy unlike idiopathic Parkinson’s Disease. Vol. 8 Frontiers in neurology, 2017.
- Plate, A, Klein, K, Pelykh, O, Singh, Anneliese, and Bötzel, K. Anticipatory postural adjustments are unaffected by age and are not absent in patients with the freezing of gait phenomenon, 2609-2618. Vol. 234, Iss. 9 Experimental brain research, 2016.
- Singh, Arun, Mewes, Klaus, Gross, Robert E., DeLong, Mahlon R., Obeso, José A., and Papa, Stella M.. Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease, 9629-9634. Vol. 113, Iss. 34 Proceedings of the National Academy of Sciences, 2016.
- Singh, Arun, Liang, Li, Kaneoke, Yoshiki, Cao, Xuebing, and Papa, Stella M.. Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates, 1533-1544. Vol. 113, Iss. 5 Journal of neurophysiology, 2015.
- Potts, Lisa F., Park, Eun S., Woo, Jong‐Min, Dyavar Shetty, Bhagya L., Singh, Arun, Braithwaite, Steven P., Voronkov, Michael, Papa, Stella M., and Mouradian, M M.. Dual κ‐agonist/μ‐antagonist opioid receptor modulation reduces levodopa‐induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of P arkinson disease, 930-941. Vol. 77, Iss. 6 Annals of neurology, 2015.
- Singh, Arun, Gutekunst, Claire A., Uthayathas, Subramaniam, Finberg, John P., Mewes, Klaus, Gross, Robert E., Papa, Stella M., and Feld, Yair. Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates, 705-713. Vol. 31, Iss. 6 Neuroscience bulletin, 2015.
- Kammermeier, S, Singh, Arun, Noachtar, S, Krotofil, I, and Bötzel, K. Intermediate latency evoked potentials of cortical multimodal vestibular areas: acoustic stimulation, 614-625. Vol. 126, Iss. 3 Clinical Neurophysiology, 2015.
- Potts, Lisa F., Wu, Hao, Singh, Arun, Marcilla, Irene, Luquin, Maria R., and Papa, Stella M.. Modeling Parkinson's disease in monkeys for translational studies, a critical analysis, 133-143. Vol. 256 Experimental neurology, 2014.
- Levin, Johannes, Singh, Arun, Feddersen, Berend, Mehrkens, Jan‐Hinnerk, and Bötzel, Kai. Onset latency of segmental dystonia after deep brain stimulation cessation: A randomized, double‐blind crossover trial, 944-949. Vol. 29, Iss. 7 Movement Disorders, 2014.
- Singh, Arun, Plate, Annika, Kammermeier, Stefan, Mehrkens, Jan H., Ilmberger, Josef, and Bötzel, Kai. Freezing of gait-related oscillatory activity in the human subthalamic nucleus, 25-32. Vol. 3, Iss. 1 Basal Ganglia, 2013.
- Singh, Arun, and Bötzel, Kai. Globus pallidus internus oscillatory activity is related to movement speed, 3644-3649. Vol. 38, Iss. 11 European Journal of Neuroscience, 2013.
- Singh, Arun. Pathophysiological Neuronal Oscillations: Invasive Recordings from the Basal Ganglia. In Textbook of Movement Disorders.
- Singh, Arun, Mehrkens, Jan H., and Bötzel, Kai. Effect of micro lesions of the basal ganglia on ballistic movements in patients with deep brain stimulation, 175-177. Vol. 314, Iss. 1-2 Journal of the neurological sciences, 2012.
- Singh, Arun, Kammermeier, Stefan, Mehrkens, Jan H., and Bötzel, Kai. Movement kinematic after deep brain stimulation associated microlesions, 1022-1026. Vol. 83, Iss. 10 J Neurol Neurosurg Psychiatry, 2012.
- Singh, Arun, Levin, Johannes, Mehrkens, Jan H., and Bötzel, Kai. Alpha frequency modulation in the human basal ganglia is dependent on motor task, 960-967. Vol. 33, Iss. 5 European Journal of Neuroscience, 2011.
- Singh, Arun, Kammermeier, Stefan, Plate, Annika, Mehrkens, Jan H., Ilmberger, Josef, and Bötzel, Kai. Pattern of local field potential activity in the globus pallidus internum of dystonic patients during walking on a treadmill, 162-167. Vol. 232, Iss. 2 Experimental neurology, 2011.
- Sharma, Varsha, Babu, P P., Singh, Arun, Singh, Sangeeta, and Singh, Rameshwar. Iron-induced experimental cortical seizures: electroencephalographic mapping of seizure spread in the subcortical brain areas, 680-690. Vol. 16, Iss. 8 Seizure, 2007.
- Travel award , Movement Disorder Society, 2018
- Travel award, MONA2, University of Pittsburgh, 2016
- Travel award, World Parkinson Congress, 2016
- Travel award, World Parkinson Congress, 2013
- Best publication award, LMU, Munich, 2011
- Travel award, EFNS , 2011
- Travel award, Movement Disorder Society, 2011
- Travel award, World Federation of Neurology, 2009
- DFG Research Fellowship, Deutsche Forschungsgemeinschaft, 2008
- Junior Research Fellowship, DST, India, 2006
- Postgraduate Fellowship, DBT, India, 2004
