Xuejun Wang

Ahammed, M S., and Wang, Xuejun. Promoting proteostasis by cAMP/PKA and cGMP/PKG.. Trends in molecular medicine, 2024. (DOI: 10.1016/j.molmed.2024.10.006)

Cai, Mingqi, Pan, Bo, Xiao, Peng, Bouska, Mark, Lewno, Megan T., Xing, Yue, Zeng, Erliang, Liang, Huiyun, Li , Faqian, Gao, Xiang, and Wang, Xuejun. Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity., 1302-1305. Vol. 150, Iss. 16 Circulation, 2024. (DOI: 10.1161/CIRCULATIONAHA.124.070067)

Cai, M, Wu, P, Ni, W, Huang, D, and Wang, Xuejun. mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges., e15966. Vol. 12, Iss. 5 Physiological reports, 2024. (DOI: 10.14814/phy2.15966)

Bai, Y, Zhang, X, Li , Y, Qi, F, Liu, C, Ai, X, Tang, M, Szeto, C, Gao, E, Hua, X, Xie, M, Wang, Xuejun, Tian, Y, Chen, Y, Huang, G, Zhang, J, Xiao, W, Zhang, L, Liu, X, Yang, Q, Houser, S R., and Chen, X. Protein Kinase A Is a Master Regulator of Physiological and Pathological Cardiac Hypertrophy., 393-410. Vol. 134, Iss. 4 Circulation research, 2024. (DOI: 10.1161/CIRCRESAHA.123.322729)

Yang, Liuqing, Parajuli, Nirmal, Wu, Penglong, Liu, Jinbao, and Wang, Xuejun. S14-Phosphorylated RPN6 Mediates Proteasome Activation by PKA and Alleviates Proteinopathy, 572-587. Vol. 133, Iss. 7 Circulation Research, 2023. (DOI: 10.1161/CIRCRESAHA.123.322887)

Lira, Jose R., Guymon, Andrew L., Yang, Liuqing, Sternburg, Jack O., Giri, Samiksha, and Wang, Xuejun. The double-hit protocol induces HFpEF and impairs myocardial ubiquitin-proteasome system performance in FVB/N mice. Vol. 14 Frontiers in Physiology, 2023. (DOI: 10.3389/fphys.2023.1208153)

Giri, Samiksha, Suo, Chao, Pardi, Ruggero, Fishbein, Gregory A., Rezvani, Khosrow, Chen, Yabing, and Wang, Xuejun. COP9 Signalosome Promotes Neointimal Hyperplasia via Deneddylation and CSN5-Mediated Nuclear Export [preprint]. In bioRxiv. Cold Spring Harbor Laboratory, 2023. (DOI: 10.1101/2023.04.11.536468)

Zhang, Lei, Cui, Taixing, and Wang, Xuejun. The Interplay between Autophagy and Regulated Necrosis. Antioxidants & Redox Signaling, 2022. (DOI: 10.1089/ars.2022.0110)

Huber, C C., Wang, Xuejun, and Wang, Hongmin. Impact of Cardiovascular Diseases on Ischemic Stroke Outcomes., 138. Vol. 21, Iss. 5 Journal of integrative neuroscience, 2022. (DOI: 10.31083/j.jin2105138)

Wu, P, Li , Y, Cai, M, Ye, B, Geng, B, Li , F, Zhu, H, Liu, J, and Wang, Xuejun. Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure., 866901. Vol. 9 Frontiers in cardiovascular medicine, 2022. (DOI: 10.3389/fcvm.2022.866901)

Geng, Bingchuan, Wang, Xiaoliang, Park, Ki H., Lee, Kyung E., Kim, Jongsoo, Chen, Peng, Zhou, Xinyu, Tan, Tao, Yang, Chunlin, Zou, Xunchang, Janssen, Paul M., Cao, Lei, Ye, Lei, Wang, Xuejun, Cai, Chuanxi, and Zhu, Hua. UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway, 102295. Vol. 52 Redox Biology, 2022. (DOI: 10.1016/j.redox.2022.102295)

Wang, Xuejun. Chapter 16. Protein degradation in cardiac health and disease. . In Proteostasis and Proteolysis, editors Niki Chondrogianni, Elah Pick, Anna Gioran, 213-224. Iss. 1st New York: CRC Press: Taylor & Francis Group, 2021.

Hussain, Anwar, Mariappan, Kadarkaraisamy, Cork, Dawson C., Lewandowski, Luke D., Shrestha, Prem K., Giri, Samiksha, Wang, Xuejun, and Sykes, Andrew. A highly selective pyridoxal-based chemosensor for the detection of Zn(ii) and application in live-cell imaging; X-ray crystallography of pyridoxal-TRIS Schiff-base Zn(ii) and Cu(ii) complexes, 34181-34192. Vol. 11, Iss. 54 RSC ADVANCES, 2021. (DOI: 10.1039/d1ra05763d)

Wu, P, Cai, Mingqi, Liu, J, and Wang, Xuejun. Catecholamine Surges Cause Cardiomyocyte Necroptosis via a RIPK1-RIPK3-Dependent Pathway in Mice., 740839. Vol. 8 Frontiers in cardiovascular medicine, 2021. (DOI: 10.3389/fcvm.2021.740839)

Li, Yanling, Liu, Huiyuan, Chen, Keng, Wu, Xueheng, Wu, Jiawen, Yang, Zhenjun, Yao, Leyi, Wen, Guanmei, Zhang, Change, Chen, Xin, Chen, Xiaohui, Tang, Daolin, Wang, Xuejun, and Liu, Jinbao. Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy. Vol. 8 Frontiers in Medicine, 2021. (DOI: 10.3389/fmed.2021.706407)

Lewno, Megan T., Cui, Taixing, and Wang, Xuejun. Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes. Vol. 12 FRONTIERS IN PHYSIOLOGY, 2021. (DOI: 10.3389/fphys.2021.690423)

Wu, W, Qin, Q, Ding, Y, Zang, H, Li , D S., Nagarkatti, M, Nagarkatti, P, Wang, W, Wang, Xuejun, and Cui, T. Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts., 673145. Vol. 12 Frontiers in physiology, 2021. (DOI: 10.3389/fphys.2021.673145)

Ranek, M J., Bhuiyan, M S., and Wang, Xuejun. Editorial: Targeting Cardiac Proteotoxicity., 669356. Vol. 12 Frontiers in physiology, 2021. (DOI: 10.3389/fphys.2021.669356)

Klionsky, Daniel J., Many Other Authors, Wang, Xuejun, and et al.. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) , 1-382. Vol. 17, Iss. 1 Autophagy, 2021. (DOI: 10.1080/15548627.2020.1797280)

Liu, Y, Subedi, K, Baride, Aravind, Romanova, S, Callegari, E, Huber, C C., Wang, Xuejun, and Wang, Hongmin. Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury., 29. Vol. 18, Iss. 1 Journal of Neuroinflammation, 2021. (DOI: 10.1186/s12974-021-02081-7)

Gao, H, Antony, R, Srinivasan, R, Wu, P, Wang, Xuejun, and Li, Yi-Fan. UCHL1 regulates oxidative activity in skeletal muscle., e0241716. Vol. 15, Iss. 11 PloS One, 2020. (DOI: 10.1371/journal.pone.0241716)

Su, H, and Wang, Xuejun. Proteasome malfunction activates the PPP3/calcineurin-TFEB-SQSTM1/p62 pathway to induce macroautophagy in the heart., 1-3. Autophagy, 2020. (DOI: 10.1080/15548627.2020.1816666)

Zang, H, Wu, W, Qi, L, Tan, W, Nagarkatti, P, Nagarkatti, M, Wang, Xuejun, and Cui, T. Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice., 2720-2734. Vol. 69, Iss. 12 Diabetes, 2020. (DOI: 10.2337/db19-1176)

Zhong, Xiaomei, Liao, Yuning, Chen, Xinru, Mai, Naikeng, Ouyang, Cong, Chen, Ben, Zhang, Min, Peng, Qi, Liang, Wanyuan, Zhang, Weiru, Wu, Zhangying, Huang, Xingxiao, Li, Caijun, Chen, Hong, Lao, Weimin, Zhang, Chang-E, Wang, Xuejun, Ning, Yuping, and Liu, Jinbao. Abnormal Serum Bilirubin/Albumin Concentrations in Dementia Patients With Aβ Deposition and the Benefit of Intravenous Albumin Infusion for Alzheimer’s Disease Treatment, 1-13. Vol. 14, Iss. 859 Frontiers in Neuroscience, 2020. (DOI: 10.3389/fnins.2020.00859)

Xiao, P, Wang, C, Li , J, Su, Huabo, Yang, Liuqing, Wu, P, Lewno, Megan T., Liu, J, and Wang, Xuejun. COP9 Signalosome Suppresses RIPK1-RIPK3 mediated Cardiomyocyte Necroptosis in Mice., 293-294. Vol. 13, Iss. 8 Circulation-Heart failure, 2020. (DOI: 10.1161/CIRCHEARTFAILURE.120.006996)

Qi, L, Zang, H, Wu, W, Nagarkatti, P, Nagarkatti, M, Liu, Q, Robbins, J, Wang, Xuejun, and Cui, T. CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes., 59-73. Vol. 145, Iss. 8 Journal of Molecular and Cellular Cardiology, 2020. (DOI: 10.1016/j.yjmcc.2020.06.004)

Pan, Bo, Li, Jie, Parajuli, Nirmal, Tian, Zongwen, Wu, Penglong, Lewno, Megan T., Zou, Jianqiu, Wang, Wenjuan, Bedford, Lynn, Mayer, R. J., Fang, Jing, Liu, Jinbao, Cui, Taixing, Su, Huabo, and Wang, Xuejun. The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction, 502-518. Vol. 127, Iss. 4 Circulation Research, 2020. (DOI: 10.1161/CIRCRESAHA.119.316007)

Wang, Xuejun, and Wang, Hongmin. Priming the Proteasome to Protect against Proteotoxicity, 639-648. Vol. 26, Iss. 7 Trends in Molecular Medicine, 2020. (DOI: 10.1016/j.molmed.2020.02.007)

Chen, H, Liang, L, Xu, H, Xu, J, Yao, L, Li , Y, Tan, Y, Li , X, Huang, Q, Yang, Z, Wu, J, Chen, J, Huang, H, Wang, Xuejun, Zhang, C, and Liu, Jinbao. Short Term Exposure to Bilirubin Induces Encephalopathy Similar to Alzheimer's Disease in Late Life., 277 – 295. Vol. 73, Iss. 1 Journal of Alzheimer's disease : JAD, 2019. (DOI: 10.3233/JAD-190945)

Gao, H, Freeling, Jessica, Wu, P, Liang, A P., Wang, Xuejun, and Li, Yi-Fan. UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle., 116699. Life sciences, 2019. (DOI: 10.1016/j.lfs.2019.116699)

Pan, B, Lewno, M T., Wu, P, and Wang, Xuejun. Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress., 758. Vol. 10 Frontiers in physiology, 2019. (DOI: 10.3389/fphys.2019.00758)

Xia, X, Huang, C, Liao, Y, Liu, Y, He, J, Guo, Z, Jiang, L, Wang, Xuejun, Liu, J, and Huang, H. Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide., 220. Vol. 38, Iss. 1 Journal of Experimental & Clinical Cancer Research, 2019. (DOI: 10.1186/s13046-019-1227-7)

Xia, X, Liu, Y, Liao, Y, Guo, Z, Huang, C, Zhang, F, Jiang, L, Wang, Xuejun, Liu, J, and Huang, H. Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and -resistant NSCLC., 172409. European Journal of Pharmacology, 2019. (DOI: 10.1016/j.ejphar.2019.172409)

Zhang, H, Pan, B, Wu, P, Parajuli, Nirmal, Rekhter, M D., Goldberg, A L., and Wang, Xuejun. PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy., eaaw5870. Vol. 5, Iss. 5 Science Advances, 2019. (DOI: 10.1126/sciadv.aaw5870)

Liao, Y, Guo, Z, Xia, X, Liu, Y, Huang, C, Jiang, L, Wang, Xuejun, Liu, J, and Huang, H. Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer., 157. Vol. 38, Iss. 1 Journal of Experimental & Clinical Cancer Research , 2019. (DOI: 10.1186/s13046-019-1165-4)

Liu, N, Guo, Z, Xia, X, Liao, Y, Zhang, F, Huang, C, Liu, Y, Deng, X, Jiang, L, Wang, Xuejun, Liu, J, and Huang, H. Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling., 1-11. Vol. 846 European Journal of Pharmacology, 2019. (DOI: 10.1016/j.ejphar.2019.01.004)

Xia, X, Liao, Y, Guo, Z, Li , Y, Jiang, L, Zhang, F, Huang, C, Liu, Y, Wang, Xuejun, Liu, N, Liu, J, and Huang, H. Targeting proteasome-associated deubiquitinases as a novel strategy for the treatment of estrogen receptor-positive breast cancer., 75. Vol. 7, Iss. 9 Oncogenesis, 2018. (DOI: 10.1038/s41389-018-0086-y)

Hu, C, Tian, Y, Xu, H, Pan, B, Terpstra, E M., Wu, P, Wang, Hongmin, Li , F, Liu, J, and Wang, Xuejun. Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury.. The Journal of Clinical Investigation, 2018. (DOI: 10.1172/JCI98287)

Chen, X, Yang, Q, Chen, J, Zhang, P, Huang, Q, Zhang, X, Yang, L, Xu, D, Zhao, C, Wang, Xuejun, and Liu, J. Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells., 780-797. Vol. 49, Iss. 2 Cellular Physiology and Biochemistry , 2018. (DOI: 10.1159/000493041)

Sane, S, Hafner, A, Srinivasan, R, Masood, D, Slunecka, J L., Noldner, C J., Hanson, A D., Kruisselbrink, T, Wang, Xuejun, Wang, Y, Yin, J, and Rezvani, Khosrow. UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells.. Molecular Oncology, 2018. (DOI: 10.1002/1878-0261.12372)

Reihe, Casey A., Pekas, Nickolas, Wu, Penglong, and Wang, Xuejun. Systemic inhibition of neddylation by 3-day MLN4924 treatment regime does not impair autophagic flux in mouse hearts and brains., 134-150. Vol. 7, Iss. 6 American journal of cardiovascular disease, 2017.

Hou, N, Wen, Y, Yuan, X, Xu, H, Wang, Xuejun, Li , F, and Ye, B. Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy.. Experimental and molecular pathology, 2017. (DOI: 10.1016/j.yexmp.2017.11.006)

Chen, X, Wu, J, Yang, Q, Zhang, X, Zhang, P, Liao, S, He, Z, Wang, Xuejun, Zhao, C, and Liu, J. Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.. BioMetals , 2017. (DOI: 10.1007/s10534-017-0062-6)

Pan, B, Zhang, H, Cui, T, and Wang, Xuejun. TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux.. Journal of Molecular and Cellular Cardiology, 2017. (DOI: 10.1016/j.yjmcc.2017.10.003)

Chen, X, Zhang, X, Chen, J, Yang, Q, Yang, L, Xu, D, Zhang, P, Wang, Xuejun, and Liu, J. Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells.. European journal of pharmacology, 2017. (DOI: 10.1016/j.ejphar.2017.09.003)

Abdullah, A, Eyster, Kathleen, Bjordahl, T, Xiao, P, Zeng, Erliang, and Wang, Xuejun. Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways., 594. Vol. 8 Frontiers in physiology, 2017. (DOI: 10.3389/fphys.2017.00594)

Lan, X, Zhao, C, Chen, X, Zhang, P, Zang, D, Wu, J, Chen, J, Long, H, Yang, L, Huang, H, Wang, Xuejun, Shi, X, and Liu, Jinbao. Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation., e2913. Vol. 8, Iss. 7 Cell death & disease, 2017. (DOI: 10.1038/cddis.2017.284)

Wu, P, Yuan, X, Li , F, Zhang, J, Zhu, W, Wei, M, Li , J, and Wang, Xuejun. Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.. Vol. 10, Iss. 7 Circulation. Heart failure, 2017. (DOI: 10.1161/CIRCHEARTFAILURE.117.004044)

Cai, J, Xia, X, Liao, Y, Liu, N, Guo, Z, Chen, J, Yang, L, Long, H, Yang, Q, Zhang, X, Xiao, L, Wang, Xuejun, Huang, H, and Liu, J. A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.. Oncotarget, 2017. (DOI: 10.18632/oncotarget.18774)

Huang, H, Guo, M, Liu, N, Zhao, C, Chen, H, Wang, Xuejun, Liao, S, Zhou, P, Liao, Y, Chen, X, Lan, X, Chen, J, Xu, D, Li , X, Shi, X, Yu, L, Nie, Y, Wang, Xuejun, Zhang, C E., and Liu, Jinbao . Bilirubin neurotoxicity is associated with proteasome inhibition., e2877. Vol. 8, Iss. 6 Cell death & disease, 2017. (DOI: 10.1038/cddis.2017.274)

Wang, Xuejun. Vascular Spasm: A Newly Unraveled Cause for Cardiovascular Adversity of Proteasome Inhibition.. EBioMedicine, 2017. (DOI: 10.1016/j.ebiom.2017.06.010)

Wang, Xuejun, and Cui, T. Autophagy Modulation - A Potential Therapeutic Approach in Cardiac Hypertrophy., ajpheart.00145.2017. American journal of physiology. Heart and circulatory physiology, 2017. (DOI: 10.1152/ajpheart.00145.2017)

Xiao, L, Lan, X, Shi, X, Zhao, K, Wang, D, Wang, Xuejun, Li , F, Huang, H, and Liu, J. Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer., e2803. Vol. 8, Iss. 5 Cell death & disease, 2017. (DOI: 10.1038/cddis.2017.210)

Liao, Y, Liu, N, Hua, X, Cai, J, Xia, X, Wang, Xuejun, Huang, H, and Liu, Jinbao. Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor., e2585. Vol. 8, Iss. 2 Cell death & disease, 2017. (DOI: 10.1038/cddis.2016.477)

Li, Jie, Ma, W, Yue, G, Tang, Y, Kim, I M., Weintraub, N L., Wang, Xuejun, and Su, Huabo. Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy., 53-60. Vol. 102, Iss. 1 Journal of molecular and cellular cardiology, 2017. (DOI: 10.1016/j.yjmcc.2016.11.013)

Zhao, C, Chen, X, Yang, C, Zang, D, Lan, X, Liao, S, Zhang, P, Wu, J, Li , X, Liu, N, Liao, Y, Huang, H, Shi, X, Jiang, L, Liu, X, Dou, Q P., Wang, Xuejun, and Liu, J. Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases., 13942-13956. Vol. 8, Iss. 8 Oncotarget, 2017. (DOI: 10.18632/oncotarget.14572)

Lan, X, Zhao, C, Chen, X, Zhang, P, Zang, D, Wu, J, Chen, J, Long, H, Yang, L, Huang, H, Carter, B Z., Wang, Xuejun, Shi, X, and Liu, J. Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms., 129. Vol. 9, Iss. 1 Journal of hematology & oncology, 2016. (DOI: 10.1186/s13045-016-0359-x)

Zhao, Chong, Chen, Xin, Zang, Dan, Lan, Xiaoying, Liao, Siyan, Yang, Changshan, Zhang, Peiquan, Wu, Jinjie, Li, Xiaofen, Liu, Ningning, Liao, Yuning, Huang, Hongbiao, Shi, Xianping, Jiang, Lili, Liu, Xiuhua, He, Zhimin, Dou, Qing P., Wang, Xuejun, and Liu, Jinbao. A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy, 5916-5927. Vol. 35, Iss. 45 Oncogene, 2016. (DOI: 10.1038/onc.2016.114)

Zhao, C, Chen, X, Zang, D, Lan, X, Liao, S, Yang, C, Zhang, P, Wu, J, Li , X, Liu, N, Liao, Y, Huang, H, Shi, X, Jiang, L, Liu, X, He, Z, Wang, Xuejun, and Liu, J. Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy., 22-38. Vol. 116 Biochemical pharmacology, 2016. (DOI: 10.1016/j.bcp.2016.06.019)

Hou, N, Ye, B, Li , X, Margulies, K B., Xu, H, Wang, Xuejun, and Li , F. Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure., pii: e003010. Vol. 9, Iss. 6 Circulation. Heart failure, 2016. (DOI: 10.1161/CIRCHEARTFAILURE.116.003010)

Zhang, Lei, Hapon, M B., Goyeneche, Alicia, Srinivasan, R, Gamarra-Luques, C D., Callegari, E A., Drappeau, D D., Terpstra, E J., Pan, B, Knapp, J R., Chien, J, Wang, Xuejun, Eyster, Kathleen, and Telleria, Carlos. Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors., 1099-1117. Vol. 10, Iss. 7 Molecular oncology, 2016. (DOI: 10.1016/j.molonc.2016.05.001)

Liu, Jinbao, Su, Huabo, and Wang, Xuejun. The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart, 601-602. Vol. 12, Iss. 3 Autophagy, 2016. (DOI: 10.1080/15548627.2015.1136773)

Jiang, Lili, Zang, Dan, Yi, Songgang, Li, Xiaofen, Yang, Changshan, Dong, Xiaoxian, Zhao, Chong, Lan, Xiaoying, Chen, Xin, Liu, Shouting, Liu, Ningning, Huang, Hngbiao, Shi, Xianping, Wang, Xuejun, and Liu, Jinbao. A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment, 21565. Vol. 6 Scientific Reports, 2016. (DOI: 10.1038/srep21565)

Klionsky, Dan J., many others, ..., Wang, Xuejun, and many others, .... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), 1-222. . Vol. 12, Iss. 1 Autophagy, 2016. (DOI: 10.1080/15548627.2015.1100356)

Qin, Qingyuan, Qu, Chen, Niu, Ting, Zang, Huimei, Qi, Lei, Lyu, Linmao, Wang, Xuejun, Janicki, Joseph S., Wang, Xing Li, and Cui, Taixing. Nrf2-mediated cardiac maladaptive remodeling and dysfunction in a setting of autophagy insufficiency, 107-117. Vol. 67, Iss. 1 Hypertension, 2016. (DOI: 10.1161/HYPERTENSIONAHA.115.06062)

Cui, Taixing, Lai, Y, Janicki, Joeseph, and Wang, Xuejun. Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes., 192-202. Vol. 21, Iss. 1 Front Biosci (Landmark Ed), 2016. (DOI: 10.2741/4384 )

Huang, Hongbiao, Liao, Y, Liu, N, Hua, X, Cai, J, Yang, C, Zhao, C, Chen, X, Lan, X, Zang, D, Wu, J, Li, X, Shi, X, Wang, Xuejun, and Liu, Jibao. Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo, 2796-2808 (E-pub ahead of print on 28 Nov 2015 ). Vol. 7, Iss. 3 Oncotarget, 2015. (DOI: 10.18632/oncotarget.6425)

Su, Huabo, Li, Jie, Zhang, Hanming, Ma, Wendy, Wei, Ning, Liu, Jinbao, and Wang, Xuejun. The COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity , 956-966 (with companion editorial). Vol. 117, Iss. 11 Circ Res, 2015. (DOI: 10.1161/CIRCRESAHA.115.306783)

Wang, Xuejun. Chapter 12. Desmin Filaments and Desmin-related Myopathy, in Schatten H edit "The Cytoskeleton in Health and Disease" . In The Cytoskeleton in Health and Disease, 281-306. New York: Springer Science & Business Media, 2015.

Li, Jie, Ma, Wenxia, Li, Huizhong, Hou, Ning, Wang, Xuejun, Kim, Il-Man, Li, Faqian, and Su, Huabo. NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes Proteasomal Degradation of Misfolded Proteins., 23850-23862. Vol. 290, Iss. 39 J Biol Chem, 2015. (DOI: 10.1074/jbc.M115.664375)

Ranek, Mark, Zheng, Hanqiao, Huang, Wei, Kumarapeli, Asnagi R., Li, Jie, Liu, Jinbao, and Wang, Xuejun. Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload, 273-281 (with companion editorial). Vol. 85, Iss. Aug J Mol Cell Cardiol, 2015. (DOI: 10.1016/j.yjmcc.2015.06.014.)

Shi, Xianping, Lan, Xiaoying, Chen, Xin, Zhao, Chong, Li, Xiaofen, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Zhang, Dan, Liao, Yuning, Zhang, Peiquan, Wang, Xuejun, and Liu, Jinbao. Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition , 9694. Vol. 5 Sci Rep, 2015. (DOI: 10.1038/srep09694.)

Zhang, Hanming, and Wang, Xuejun. Priming the proteasome: a novel mechanism for cardioprotection by sildenafil., 177–189. Vol. 11, Iss. 2 Future Cardiology , 2015.

Wang, Xuejun. Entangled in a heart-ailing quandary: could modified cofilin-2 be a culprit of Alzheimer’s disease of the heart? (invited editorial), 1215-1217 . Vol. 65, Iss. 12 Journal of American College of Cardiology (JACC), 2015. (DOI: doi: 10.1016/j.jacc.2015.01.035. )

Martin, Douglas, and Wang, Xuejun. The COP9 Signalosome and Vascular Function: Intriguing Possibilities?, 33-52. Vol. 5, Iss. 1 Am J Cardiovasc Dis, 2015.

Wang, Xuejun, and Martin, Douglas. The COP9 signalosome and Cullin RING Ligases in the heart, 1-18. Vol. 5, Iss. 1 Am J Cardiovasc Dis, 2015.

Wang, Changhua, and Wang, Xuejun. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity, 188-94. Vol. 1852, Iss. 2 BBA - Molecular Basis of Disease, 2015. (DOI: 10.1016/j.bbadis.2014.07.028)

Chen , X, Shi, X, Wang, Xuejun, and Liu, Jinbao. Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells. , e415. Vol. 1 Can Cell Microenviron , 2014. (DOI: 10.14800/ccm.415)

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Liu, Y., Hettinger, C. L., Zhang, Dong, Rezvani, Khosrow, Wang, Xuejun, and Wang, Hongmin. Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington’s disease, 539-47. Epub 2014 Jan 18.. Vol. 129, Iss. 3 J Neurochem, 2014. (DOI: 10.1111/jnc.12647)

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Liu, Y., Hettinger, C. L., Zhang, Dong, Rezvani, Khosrow, Wang, Xuejun, and Wang, Hongmin. The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model, 315-322. Epub 2013 Dec 21. . Vol. 34, Iss. 3 Cell Mol Neurobiol, 2014. (DOI: 10.1007/s10571-013-0022-9)

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Liu, Cheng, Guo, Liquan, Menon, Suchithra, Jin, Dan, Pick, Elah, Wang, Xuejun, Deng, Xingwang, and Wei, Ning. COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase, 20443-52. PMID: 23689509 [PubMed]. Vol. 288, Iss. 28 Journal of Biological Chemistry, 2013. (DOI: 10.1074/jbc.M113.468959)

Lei, Daoxiong, Li, Faqian, Su, Huabo, Liu, Jinbao, Wei, Ning, and Wang, Xuejun. Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-mediated Apoptosis in Murine Livers, e67793. PMID: 23840878 [PubMed]. Vol. 8, Iss. 7 PLOS ONE, 2013. (DOI: 10.1371/journal.pone.0067793)

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Wang, Xuejun, and Patterson, Cam. Chapter 27. Protein quality control in cardiomyocytes; In: Hill JA, Olson EN, eds. Muscle: Fundamental Biology and Mechanisms and Disease. . In Muscle: Fundamental Biology and Mechanisms of Disease, 353-368. Vol. 1, Iss. 1 San Diego, CA: Elsevier, 2012.

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Wang, Xuejun, and Su, Huabo. FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice. In Cardiovascular Research, 561-562. Vol. 91, Iss. 4 Cardiovascular Research, 2011. (DOI: 10.1093/cvr/cvr196)

Li, Jie, Horak, K. M., Su, Huabo, Sanbe, Atsushi, Robbins, Jeff, and Wang, Xuejun. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice.. In Journal of Clinical Investigation, 3689-3700. Vol. 121, Iss. 9 Journal of Clinical Investigation, 2011. (DOI: 10.1172/JCI45709)

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Su, Huabo, Li, Jie, Menon, Suchithra , Liu, Jinbao, Kumarapeli, Asangi R., Wei, Ning, and Wang, Xuejun. Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.. In Circulation Research, 40-50. Vol. 108, Iss. 1 Circulation Research, 2011. (DOI: 10.1161/CIRCRESAHA.110.230607)

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Zheng, Hanqiao, Tang, Mingxin, Zheng, Qingwen, Kumarapeli, Asangi R., Horak, Kathy M., Tian, Zongwen, and Wang, Xuejun. Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy, 1418-1426. Vol. 56, Iss. 17 Journal of the American College of Cardiology , 2010. (DOI: doi:10.1016/j.jacc.2010.01.075)

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Lei, Daoxiong, Li, Faqian, Su, Huabo, Tian, Zongwen, Ye, B, Wei, Ning, and Wang, Xuejun. COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation, 259-70. Vol. 18, Iss. 2 Cell Death Differ, 2010. (DOI: 10.1038/cdd.2010.98)

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Tang, Mingxin, Li, Jie, Wei, Huang, Su, Huabo, Liang, Qiangrong, Tian, Zongwen, Horak, Kathlene, Molkentin, Jeffery, and Wang, Xuejun. Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts, 424-33. Vol. 88, Iss. 3 Cardiovasc Res, 2010.

Su, Huabo, and Wang, Xuejun. The Ubiquitin-Proteasome System in Cardiac Proteinopathy: A Quality Control Perspective, 253-62. Vol. 85, Iss. 2 Cardiovasc Res, 2010.

Wang, Xuejun, and Su, Huabo. Unraveling enigma in the z-disks, 321-3. Vol. 107, Iss. 3 Circ Res, 2010.

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Ranek, Mark J., and Wang, Xuejun. Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy, 389-385. Vol. 11, Iss. 6 Curr Hypertens Rep, 2009.

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Su, Huabo, Huang, Wei, and Wang, Xuejun. The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription, 615-24. Vol. 41, Iss. 3 Int J Biochem Cell Biol, 2009.

Tydlacka, S., Wang, C. E., Wang, Xuejun, Li, S., and Li, Xiao J.. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons, 13285-13295. Vol. 28, Iss. 49 The Journal of Neuroscience, 2008.

Liu, Jinbao, Zheng, Hanqiao, Tang, Mingxin, Ryu, Youn-Chu, and Wang, Xuejun. A therapeutic dose of doxorubicin activate ubiquitin-proteasome system mediated proteolysis by acting on both ubiquitination apparatus and the proteasome, H2541-2550. Vol. 295, Iss. 6 American Journal of Physiology Heart and Circulatory Physiology , 2008.

Powell, Saul R., Samuel , S M., Wang, P., Divald, A., Thirunavukkarasu, M., Koneru, S., Wang, Xuejun, and Maulik, N.. Upregulation of myocardial 11S-activated proteasome in experimental hyperglycermia, 618-621. Vol. 44, Iss. 3 J Mol Cell Cardiol, 2008.

Kumarapeli, Asangi R., Su, Huabo, Wei, Huang, Tang, Mingxin, Zheng, Hanqiao, Horak, Kathelene M., Li, Manxiang, and Wang, Xuejun. AlphaB-crystallin suppresses pressure overload cardiac hypertrophy. . , 1473-82. Vol. 103, Iss. 12 Circ Res, 2008.

Wang, Xuejun, Su, Huabo, and Mark, Ranek M.. Protein quality control and degradation in cardiomyocytes, 11-27. Vol. 457, Iss. 1 J Mol Cell Cardiol, 2008.

Qu, Jiaxiang, Zhou, Jibin, Yi, Xian-Ping, Dong, Baojun, Zheng, Hanqiao, Miller, Lisa M., Wang, Xuejun, Schneider, Mike D., and Li, Faqian. Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction, 319-326. Vol. 43, Iss. 3 J Mol Cell Cardiol, 2007.

Kobayashi, S., Mao, Kai, Zheng, Hanqiao, Wang, Xuejun, Patterson, Cam , O'Connell, Tim D., and Liang, Qiangrong. Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury, 21945-21952. Vol. 282, Iss. 30 J Biol Chem, 2007.

Zhou, Jibin, Qu, Jiaxiang, Yi, Xian-Ping, Graber, K., Huber, L, Wang, Xuejun, Gerdes, A. M., and Li, Faqian. Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes, H270-H276. Vol. 292, Iss. 1 Am J Physiol Heart Circ Physiol, 2007.

Wang, Xuejun, and Robbins, Jeffrey. Heart failure and protein quality control, 1315-1328. Vol. 99, Iss. 12 Circulation Research, 2006.

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Liu, Jinbao, Tang, Mingxin, Mestril, Ruben, and Wang, Xuejun. Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes, 451-454. Vol. 40, Iss. 4 J Mol Cell Cardiol, 2006.

Liu, Jinbao, Chen, Quanhai, Huang, Wei , Horak, Kathy, Zheng, Hanqiao, Mestril, Ruben, and Wang, Xuejun. Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts, 362-364. Vol. 20, Iss. 2 FASEB Journal, 2006.

Tang, Yi-Da, Kuzman, J. A., Said, S. , Anderson, B. E., Wang, Xuejun, and Gerdes, A. M.. Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction, 122-130. Vol. 112, Iss. 20 Circulation, 2005.

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Gard, J J., Yamada, K, Green, K G., Eloff, B C., Rosenbaum, D S., Wang, Xuejun, Robbins, Jeff, Schuessler, R B., Yamada, K A., and Saffitz, Jeff E.. Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy., 539-547. Vol. 67, Iss. 3 Cardiovasc Res, 2005.

Yi, Xian-Ping, Zhou, Jibin, Baker, J., Wang, Xuejun, Gerdes, A. M., and Li, Faqian. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure, 13-23. Vol. 282, Iss. 1 Anat Rec A Discov Mol Cell Evol Biol, 2005.

Kumarapeli, Asangi R., and Wang, Xuejun. Genetic modification of the heart: chaperones and the cytoskeleton, 1097-1109. Vol. 37, Iss. 6 J Mol Cell Cardiol, 2004.

Dong, Xin, Liu, Jinbao, Zheng, Hanqiao, Glasford, Joe W., Hunag, Wei, Chen, Quan H., Harden, Niel R., Li, Faqian, Gerdes, A. M., and Wang, Xuejun. In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes, H1417-1425. Vol. 287, Iss. 3 Am J Physiol Heart Circ Physiol, 2004.

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Yi, Xian-Ping, Wang, Xuejun, Gerdes, A. M., and Li, Faqian. Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium, 1317-1323. Vol. 41, Iss. 6 Hypertension, 2003.

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Wang, Xuejun, Osinska, Hanna, Gerdes, A. M., and Robbins, Jeff. Desmin filaments and cardiac disease: establishing causality, S287-292. Vol. 8, Iss. 6 Suppl J Card Fail, 2002.

Wu, Guangyu, Yussman, M. G., Barrett, T. J., Hahn, H. S., Osinska, Hanna, Hilliard, G. M., Wang, Xuejun, Toyokawa, T., Yatani, A., Lynch, R. A., Robbins, Jeff, and Dorn, Gerald W.. Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy, 1130-1137. Vol. 89, Iss. 12 Circ Res, 2001.

Wang, Xuejun, Osinska, Hanna, Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, Tim, and Robbins, Jeff. Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice, 84-91. Vol. 89, Iss. 1 Circ Res, 2001.

Yang, Q., Hewett, T. E., Klevitsky, R., Sanbe, A., Wang, Xuejun, and Robbins, Jeff. PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice, 80-88. Vol. 51, Iss. 1 Cardiovasc Res, 2001.

Wang, Xuejun, Osinska, H. , Dorn, Gerald W., Nieman, M., Lorenz, Jon N., Gerdes, A. M., Witt, S., Kimball, Tom, Gulick, Jim, and Robbins, Jeff. Mouse model of desmin-related cardiomyopathy, 2402-2407. Vol. 103, Iss. 19 Circulation, 2001.

Sanbe, A., Nelson, D., Gulick, Jim, Setser, E., Osinska, Hanna, Wang, Xuejun, Hewett, Tim E., Klevitsky, R., Hayes, E., Warshaw, David M., and Robbins, Jeff. In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy, 296-302. Vol. 87, Iss. 4 Circ Res, 2000.

Milner, Derek J., Taffet, G E., Wang, Xuejun, Pham, T, Tamura , T, Hartley, C, Gerdes, A. M., and Capetanaki, Y. The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function, 2063-76. Vol. 31, Iss. 11 J Mol Cell Cardiol , 1999. (DOI: 10.1006/jmcc.1999.1037)

Wang, Xuejun, Li, Faqian, and Gerdes, A. M.. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling, 307-317. Vol. 31, Iss. 2 J Mol Cell Cardiol, 1999.

Wang, Xuejun, Li, Faqian, Campbell, Scott E., and Gerdes, A. M.. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling, 319-331. Vol. 31, Iss. 2 J Mol Cell Cardiol, 1999.

Wang, Xuejun, and Gerdes, A. M.. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling, 333-343. Vol. 31, Iss. 2 J Mol Cell Cardiol, 1999.

Li, Faqian, Wang, Xuejun, Bunger, Paul, and Gerdes, A. M.. Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring, 1541-1551. Vol. 29, Iss. 6 J Mol Cell Cardiol, 1997.

Li, Faqian, Wang, Xuejun, and Gerdes, A. M.. Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation, 1553-1565. Vol. 29, Iss. 6 J Mol Cell Cardiol, 1997.

Wang, Xuejun, Li, Faqian, Said, Suleman, Capasso, Joe M., and Gerdes, A. M.. Measurement of regional myocardial blood flow in rats by unlabeled microspheres and Coulter channelyzer, H1656-1665. Vol. 271, Iss. 4 Pt 2 Am J Physiol, 1996.

Gerdes, A. M., Onodera, T., Wang, Xuejun, and McCune, S. A.. Myocyte remodeling during the progression to failure in rats with hypertension, 609-614. Vol. 28, Iss. 4 Hypertension, 1996.

Li, Faqian, Wang, Xuejun, Capasso, Joe M., and Gerdes, A. M.. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development, 1737-1746. Vol. 28, Iss. 8 J Mol Cell Cardiol, 1996.

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