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Cardiovascular and Renal Physiology
The primary goal of my research is to elucidate the role of the central nervous system in the control of sympathetic outflow leading to regulation of blood pressure, cardiac function, renal function, and blood volume under normal and pathological states, such as heart failure, diabetes and obesity. I have been engaging in studying the neural control of cardiovascular and renal function in chronic heart failure and obese hypertension. In particular, I am interested in investigating the interactions of neurohumoral components and adipokines (including leptin, GLP-1) regulation of sympathetic activity, blood pressure and kidney function. Currently, NIH-funded research project in my lab includes studies of the role of renal sympathetic nerve regulating sodium-glucose co-transporter 2 in chronic heart failure, and the therapeutic benefits of renal denervation on sodium fluid retention endemic to chronic heart failure. In the past 20 years, I have obtained wide knowledge about neurophysiology and cardiovascular physiology, with experimental expertise (such as electrophysiological nerve activity recording, cardiovascular and renal functions in conscious and anesthetized animals, microdialysis, molecular biology techniques, adenoviral gene transfection, immunohistochemistry, Ca2+ image, neuronal cell culture).
