Lisa McFadden

Drug addiction is a chronic, relapsing and debilitating disorder. Understanding the biological changes underlying addiction is imperative for developing effective interventions. My laboratory’s research focuses on understanding the changes in the brain that occurs following methamphetamine use in a preclinical model of drug addiction. Additionally, we strive to understand the role of sex/gender in these changes. Ultimately, the goal of this research is to use these findings to develop effective interventions for drug addiction.

Now accepting students.

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

Dolezal, A, Severson, MA, Ali, R, Dohn, P, and McFadden, Lisa. Analysis of substance use and suicidal ideation in Midwestern frontier and non-frontier locations., 24-27. Vol. 76(1) South Dakota Medicine, 2023.
Severson, MA, Cassada, DA, Huber, VC, Snow, DD, and McFadden, Lisa. Population Health Metrics During the Early Stages of the COVID-19 Pandemic: Correlative Pilot Study., e40215. Vol. 6(10) JMIR Form Res, 2022. (DOI: 10.2196/40215)
McFadden, Lisa, Goodman Shepherd, J, Burrell, B, Scholl, JL, and Forster, G. Engaging Undergraduate Students in Substance Use and Related Mental Health Disorders Research within South Dakota: A Review of the Summer Program for Undergraduate Research in Addiction (SPURA). , 264-271. Vol. 74(6) South Dakota Medicine, 2021.
Goodman Shepherd, J, McFadden, Lisa, and Burrell, B. Encouraging a Commitment to Research: Helping Students Understand the Opioid and METH Epidemics Across Disciplines.. Midwest Medical Edition, 2020.
Freeling, J, and McFadden, Lisa. The Emergence of Cardiac Changes following the Self-Administration of Methamphetamine., 108029. Vol. 212 Drug Alcohol Depend, 2020. (DOI: 10.1016/j.drugalcdep.2020.108029)
Anderson, EM, McFadden, Lisa, and Matuszewich, L. Interaction of Stress and Stimulants in Female Rats: Role of Chronic Stress on Later Reactivity to Methamphetamine. . Vol. 376, Iss. 112176 Behav Brain Res, 2019.
Cordie, R, and McFadden, Lisa. Optogenetic Inhibition of the Medial Prefrontal Cortex Reduces Methamphetamine-Primed Reinstatement in Male and Female Rats. Behavioural Pharmacology. , 506-513. Vol. 30(6) Behavioural Pharmacology, 2019. (DOI: 10.1097/FBP.0000000000000485)
McFadden, Lisa, Cordie, R, Livermont, T, and Johansen, A. Behavioral and Serotonergic Changes in the Frontal Cortex Following Methamphetamine Self-Administration., 758-763. Vol. 21(8) Int J Neuropsychopharmacol, 2018. (DOI: 10.1093/ijnp/pyy044)
Anderson, EM, McWaters, ML, McFadden, Lisa, and Matuszewich, L. Defensive Burying as an Ethological Approach to Studying Anxiety: Influence of Juvenile Methamphetamine on Adult Defensive Burying Behavior in Rats., 97-106. Vol. 61 Learning and Motivation, 2018. (DOI: https://doi.org/10.1016/j.lmot.2017.02.001)
Johansen, A, and McFadden, Lisa. The Neurochemical Consequences of Methamphetamine Self-Administration in Male and Female Rats. , 70-74. Vol. 178 Drug and Alcohol Dependence, 2017. (DOI: 10.1016/j.drugalcdep.2017.04.011)
Vieira-Brock, P L., McFadden, Lisa, Nielsen, S M., Ellis, J D., Walters, E T., Stout, K A., McIntosh, J M., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits., 463-72. Vol. 355, Iss. 3 The Journal of pharmacology and experimental therapeutics, 2015. (DOI: 10.1124/jpet.114.221945)
Alburges, M E., Hoonakker, A J., Cordova, N M., Robson, C M., McFadden, Lisa, Martin, A L., and Hanson, G R.. Effect of low doses of methamphetamine on rat limbic-related neurotensin systems., 396-404. Vol. 69, Iss. 8 Synapse (New York, N.Y.), 2015. (DOI: 10.1002/syn.21829)
Vieira-Brock, P L., McFadden, Lisa, Nielsen, S M., Smith, M D., Hanson, G R., and Fleckenstein, A E.. Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits.. Vol. 18, Iss. 12 The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2015. (DOI: 10.1093/ijnp/pyv073)
McFadden, Lisa, Vieira-Brock, P L., Hanson, G R., and Fleckenstein, A E.. Prior methamphetamine self-administration attenuates the dopaminergic deficits caused by a subsequent methamphetamine exposure., 146-54. Vol. 93 Neuropharmacology, 2015. (DOI: 10.1016/j.neuropharm.2015.01.013)
German, C L., Baladi, M G., McFadden, Lisa, Hanson, G R., and Fleckenstein, A E.. Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease., 1005. Vol. 67 Pharmalogical Reviews, 2015.
Matuszewich, L, Carter, S, Anderson, E M., Friedman, R D., and McFadden, Lisa. Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress., 308-13. Vol. 272 Behavioural brain research, 2014. (DOI: 10.1016/j.bbr.2014.07.013)
Matuszewich, L, McFadden, Lisa, Friedman, R D., and Frye, C A.. Neurochemical and behavioral effects of chronic unpredictable stress., 557-66. Vol. 25, Iss. 5-6 Behavioural pharmacology, 2014. (DOI: 10.1097/FBP.0000000000000061)
McFadden, Lisa, Vieira-Brock, P L., Hanson, G R., and Fleckenstein, A E.. Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor., 1315-20. Vol. 17, Iss. 8 The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2014. (DOI: 10.1017/S1461145714000327)
Alburges, M E., Hoonakker, A J., Cordova, N M., Robson, C M., McFadden, Lisa, Martin, A L., and Hanson, G R.. Responses of the rat basal ganglia neurotensin systems to low doses of methamphetamine., 2933-40. Vol. 231, Iss. 15 Psychopharmacology, 2014. (DOI: 10.1007/s00213-014-3468-7)
McFadden, Lisa, Hanson, G R., and Fleckenstein, A E.. The effects of methamphetamine self-administration on cortical monoaminergic deficits induced by subsequent high-dose methamphetamine administrations., 875-81. Vol. 67, Iss. 12 Synapse (New York, N.Y.), 2013. (DOI: 10.1002/syn.21696)
Hanson, G R., Hoonakker, A J., Robson, C M., McFadden, Lisa, Frankel, P S., and Alburges, M E.. Response of neurotensin basal ganglia systems during extinction of methamphetamine self-administration in rat., 173-81. Vol. 346, Iss. 2 The Journal of pharmacology and experimental therapeutics, 2013. (DOI: 10.1124/jpet.113.205310)
McFadden, Lisa, Hunt, M M., Vieira-Brock, P L., Muehle, J, Nielsen, S M., Allen, S C., Hanson, G R., and Fleckenstein, A E.. Prior methamphetamine self-administration attenuates serotonergic deficits induced by subsequent high-dose methamphetamine administrations., 87-94. Vol. 126, Iss. 1-2 Drug and alcohol dependence, 2012. (DOI: 10.1016/j.drugalcdep.2012.04.020)
McFadden, Lisa, Carter, S, and Matuszewich, L. Juvenile exposure to methamphetamine attenuates behavioral and neurochemical responses to methamphetamine in adult rats., 118-22. Vol. 229, Iss. 1 Behavioural brain research, 2012. (DOI: 10.1016/j.bbr.2012.01.013)
McFadden, Lisa, Stout, K A., Vieira-Brock, P L., Allen, S C., Nielsen, S M., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Methamphetamine self-administration acutely decreases monoaminergic transporter function., 240-5. Vol. 66, Iss. 3 Synapse (New York, N.Y.), 2012. (DOI: 10.1002/syn.21506)
Hanson, G R., Hoonakker, A J., Alburges, M E., McFadden, Lisa, Robson, C M., and Frankel, P S.. Response of limbic neurotensin systems to methamphetamine self-administration., 99-107. Vol. 203 Neuroscience, 2012. (DOI: 10.1016/j.neuroscience.2011.12.037)
McFadden, Lisa, Hadlock, G C., Allen, S C., Vieira-Brock, P L., Stout, K A., Ellis, J D., Hoonakker, A J., Andrenyak, D M., Nielsen, S M., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure., 295-303. Vol. 340, Iss. 2 The Journal of pharmacology and experimental therapeutics, 2012. (DOI: 10.1124/jpet.111.188433)
Hadlock, G C., Webb, K M., McFadden, Lisa, Chu, P W., Ellis, J D., Allen, S C., Andrenyak, D M., Vieira-Brock, P L., German, C L., Conrad, K M., Hoonakker, A J., Gibb, J W., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse., 530-6. Vol. 339, Iss. 2 The Journal of pharmacology and experimental therapeutics, 2011. (DOI: 10.1124/jpet.111.184119)
McFadden, Lisa, Hoonakker, A J., Vieira-Brock, P L., Stout, K A., Sawada, N M., Ellis, J D., Allen, S C., Walters, E T., Nielsen, S M., Gibb, J W., Alburges, M E., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Methamphetamine treatment during development attenuates the dopaminergic deficits caused by subsequent high-dose methamphetamine administration., 771-7. Vol. 65, Iss. 8 Synapse (New York, N.Y.), 2011. (DOI: 10.1002/syn.20902)
Frankel, P S., Hoonakker, A J., Alburges, M E., McDougall, J W., McFadden, Lisa, Fleckenstein, A E., and Hanson, G R.. Effect of methamphetamine self-administration on neurotensin systems of the basal ganglia., 809-15. Vol. 336, Iss. 3 The Journal of pharmacology and experimental therapeutics, 2011. (DOI: 10.1124/jpet.110.176610)
McFadden, Lisa, Paris, J J., Mitzelfelt, M S., McDonough, S, Frye, C A., and Matuszewich, L. Sex-dependent effects of chronic unpredictable stress in the water maze., 266-75. Vol. 102, Iss. 3-4 Physiology & behavior, 2011. (DOI: 10.1016/j.physbeh.2010.10.022)
McFadden, Lisa, and Matuszewich, L. The effects of methamphetamine exposure during preadolescence on male and female rats in the water maze., 99-109. Vol. 185, Iss. 2 Behavioural brain research, 2007. (DOI: 10.1016/j.bbr.2007.07.016)

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