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- William Mayhan
William Mayhan
Faculty
Dean, Basic Biomedical Science Basic Biomedical Sciences
Specialty
Brain Effects from Fetal Alcohol Syndrome
Contact Us
Cardiovascular Physiology
Our research is centered on examining two aspects of endothelial cell function in the cerebral microcirculation, i.e., regulation of vascular function and permeability of the blood-brain barrier. We examine changes in cerebral blood vessels during a variety of disease states. We believe that our studies provide insight into the pathogenesis of stroke during disease states.
- Post Doctoral Fellowship, University of Iowa, 1985
- Ph D, University of Nebraska Medical Center, 1983
- BS, Biology, Creighton University, 1977
- Influence of activation of CB2 receptors on cerebrovascular function, Diabetes Action Research and Education Foundation, (2017 - 2017)
- Light Alcohol Consumption and Ischemic Stroke, National Institutes of Heath, (2016 - 2021)
- Influence of Exercise Training on Cerebrovascular Dysfunction in T1D, National Institutes of Health, (2009 - 2014)
- Cerebral Microcirculation During Alcohol Consumption, National Institutes of Health, (2005 - 2011)
- Cerebrovascular Disease in Type 1 Diabetes, National Institutes of Heath, (2004 - 2009)
Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.
- Mayhan, William, and Arrick, Denise. Tetrahydrobiopterin rescues impaired responses of cerebral resistance arterioles during type 1 diabetes., 33-39. Vol. 14, Iss. 1 Diabetes & vascular disease research, 2017. (DOI: 10.1177/1479164116675490)
- Jackson, K L., Dhaibar, H A., Dayton, R D., Cananzi, S G., Mayhan, William, Glasscock, E, and Klein, R L.. Severe respiratory changes at end stage in a FUS-induced disease state in adult rats., 69. Vol. 17, Iss. 1 BMC neuroscience, 2016. (DOI: 10.1186/s12868-016-0304-5)
- Arrick, Denise, Li , C, and Mayhan, William. Sex-related differences in reactivity of cerebral arterioles during moderate exercise training., 549-557. Vol. 23, Iss. 7 Microcirculation (New York, N.Y. : 1994), 2016. (DOI: 10.1111/micc.12306)
- Alomar, F, Singh, J, Jang, H S., Rozanzki, G J., Shao, C H., Padanilam, B J., Mayhan, William, and Bidasee, K R.. Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats.. British journal of pharmacology, 2016. (DOI: 10.1111/bph.13617)
- Li , C, Sun, H, Arrick, Denise, and Mayhan, William. Chronic nicotine exposure exacerbates transient focal cerebral ischemia-induced brain injury., 328-33. Vol. 120, Iss. 3 Journal of applied physiology (Bethesda, Md. : 1985), 2016. (DOI: 10.1152/japplphysiol.00663.2015)
- Mayhan, William, Scott, J P., and Arrick, Denise. Influence of type 1 diabetes on basal and agonist-induced permeability of the blood-brain barrier.. Vol. 3, Iss. 12 Physiological reports, 2015. (DOI: 10.14814/phy2.12653)
- Arrick, Denise, Yang, S, Li , C, Cananzi, S, and Mayhan, William. Vigorous exercise training improves reactivity of cerebral arterioles and reduces brain injury following transient focal ischemia., 516-23. Vol. 21, Iss. 6 Microcirculation (New York, N.Y. : 1994), 2014. (DOI: 10.1111/micc.12127)
- Arrick, Denise, Sun, H, and Mayhan, William. Influence of exercise training on ischemic brain injury in type 1 diabetic rats., 1121-7. Vol. 113, Iss. 7 Journal of applied physiology (Bethesda, Md. : 1985), 2012. (DOI: 10.1152/japplphysiol.00437.2012)
- Sun, H, Xiong, W, Arrick, Denise, and Mayhan, William. Low-dose alcohol consumption protects against transient focal cerebral ischemia in mice: possible role of PPARγ., e41716. Vol. 7, Iss. 7 PloS one, 2012. (DOI: 10.1371/journal.pone.0041716)
- Zheng, H, Mayhan, William, and Patel, K P.. Exercise training improves the defective centrally mediated erectile responses in rats with type I diabetes., 3086-97. Vol. 8, Iss. 11 The journal of sexual medicine, 2011. (DOI: 10.1111/j.1743-6109.2011.02442.x)
- Zheng, Hong, Mayhan, William, and Patel, K P.. Exercise training improves the defective centrally mediated erectile responses in rats with type I diabetes., 3086-97. Vol. 8, Iss. 11 The journal of sexual medicine, 2011. (DOI: 10.1111/j.1743-6109.2011.02442.x)
- Arrick, Denise, Sun, H, Patel, K P., and Mayhan, William. Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats., H696-703. Vol. 301, Iss. 3 American journal of physiology. Heart and circulatory physiology, 2011. (DOI: 10.1152/ajpheart.00312.2011)
- Zhao, H, Mayhan, William, Arrick, Denise, Xiong, W, and Sun, H. Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury., 1265-9. Vol. 35, Iss. 7 Alcoholism, clinical and experimental research, 2011. (DOI: 10.1111/j.1530-0277.2011.01461.x)
- Mayhan, William, Arrick, Denise, Patel, K P., and Sun, H. Exercise training normalizes impaired NOS-dependent responses of cerebral arterioles in type 1 diabetic rats., H1013-20. Vol. 300, Iss. 3 American journal of physiology. Heart and circulatory physiology, 2011. (DOI: 10.1152/ajpheart.00873.2010)
- Patel, K P., Mayhan, William, Bidasee, K R., and Zheng, H. Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion., R311-20. Vol. 300, Iss. 2 American journal of physiology. Regulatory, integrative and comparative physiology, 2011. (DOI: 10.1152/ajpregu.00246.2010)
- Patel, K P., Mayhan, William, Bidasee, K R., and Zheng, Hong. Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion., R311-20. Vol. 300, Iss. 2 American journal of physiology. Regulatory, integrative and comparative physiology, 2011. (DOI: 10.1152/ajpregu.00246.2010)
- Zhao, H, Mayhan, William, Arrick, Denise, Xiong, W, and Sun, H. Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase., 1948-55. Vol. 34, Iss. 11 Alcoholism, clinical and experimental research, 2010. (DOI: 10.1111/j.1530-0277.2010.01284.x)
- Mayhan, William, Arrick, Denise, Sun, H, and Patel, K P.. Exercise training restores impaired dilator responses of cerebral arterioles during chronic exposure to nicotine., 1109-14. Vol. 109, Iss. 4 Journal of applied physiology (Bethesda, Md. : 1985), 2010. (DOI: 10.1152/japplphysiol.00564.2010)
- Arrick, Denise, and Mayhan, William. Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats., 439-46. Vol. 17, Iss. 6 Microcirculation (New York, N.Y. : 1994), 2010. (DOI: 10.1111/j.1549-8719.2010.00042.x)
- Ren, C, Du , A, Li , D, Sui, J, Mayhan, William, and Zhao, H. Dynamic change of hydrogen sulfide during global cerebral ischemia-reperfusion and its effect in rats., 197-205. Vol. 1345 Brain research, 2010. (DOI: 10.1016/j.brainres.2010.05.017)
- Shao, C H., Rozanski, G J., Nagai, R, Stockdale, F E., Patel, K P., Wang, M, Singh, J, Mayhan, William, and Bidasee, K R.. Carbonylation of myosin heavy chains in rat heart during diabetes., 205-17. Vol. 80, Iss. 2 Biochemical pharmacology, 2010. (DOI: 10.1016/j.bcp.2010.03.024)
- Mayhan, William, Arrick, Denise, Sharpe, G M., and Sun, H. Nitric oxide synthase-dependent responses of the basilar artery during acute infusion of nicotine., 270-7. Vol. 11, Iss. 3 Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2009. (DOI: 10.1093/ntr/ntn025)
- Zhao, H, Mayhan, William, and Sun, H. A modified suture technique produces consistent cerebral infarction in rats., 158-66. Vol. 1246 Brain research, 2008. (DOI: 10.1016/j.brainres.2008.08.096)
- Arrick, Denise, Sharpe, G M., Sun, H, and Mayhan, William. Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats., 128-35. Vol. 1209 Brain research, 2008. (DOI: 10.1016/j.brainres.2008.03.020)
- Mayhan, William, Arrick, Denise, Sharpe, G M., and Sun, H. Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress., 225-36. Vol. 15, Iss. 3 Microcirculation (New York, N.Y. : 1994), 2008. (DOI: 10.1080/10739680701641421)
- Sun, H, Zhao, H, Sharpe, G M., Arrick, Denise, and Mayhan, William. Influence of chronic alcohol consumption on inward rectifier potassium channels in cerebral arterioles., 367-72. Vol. 75, Iss. 3 Microvascular research, 2008. (DOI: 10.1016/j.mvr.2007.11.004)
- Sun, H, Zhao, H, Sharpe, G M., Arrick, Denise, and Mayhan, William. Effect of chronic alcohol consumption on brain damage following transient focal ischemia., 73-80. Vol. 1194 Brain research, 2008. (DOI: 10.1016/j.brainres.2007.11.061)
- Arrick, Denise, Sharpe, G M., Sun, H, and Mayhan, William. nNOS-dependent reactivity of cerebral arterioles in Type 1 diabetes., 365-71. Vol. 1184 Brain research, 2007. (DOI: 10.1016/j.brainres.2007.10.004)
- Arrick, Denise, and Mayhan, William. Acute infusion of nicotine impairs nNOS-dependent reactivity of cerebral arterioles via an increase in oxidative stress., 2062-7. Vol. 103, Iss. 6 Journal of applied physiology (Bethesda, Md. : 1985), 2007. (DOI: 10.1152/japplphysiol.00411.2007)
- Zheng, H, Bidasee, K R., Mayhan, William, and Patel, K P.. Lack of central nitric oxide triggers erectile dysfunction in diabetes., R1158-64. Vol. 292, Iss. 3 American journal of physiology. Regulatory, integrative and comparative physiology, 2007. (DOI: 10.1152/ajpregu.00429.2006)
- Arrick, Denise, Sharpe, G M., Sun, H, and Mayhan, William. Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase., 1-6. Vol. 73, Iss. 1 Microvascular research, 2007. (DOI: 10.1016/j.mvr.2006.08.001)
- Mayhan, William, Arrick, Denise, Sharpe, G M., Patel, K P., and Sun, H. Inhibition of NAD(P)H oxidase alleviates impaired NOS-dependent responses of pial arterioles in type 1 diabetes mellitus., 567-75. Vol. 13, Iss. 7 Microcirculation (New York, N.Y. : 1994), 2006. (DOI: 10.1080/10739680600885194)
- Li , Y F., Wang, W, Mayhan, William, and Patel, K P.. Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide., R1035-43. Vol. 290, Iss. 4 American journal of physiology. Regulatory, integrative and comparative physiology, 2006. (DOI: 10.1152/ajpregu.00338.2004)
- Zheng, H, Mayhan, William, Bidasee, K R., and Patel, K P.. Blunted nitric oxide-mediated inhibition of sympathetic nerve activity within the paraventricular nucleus in diabetic rats., R992-R1002. Vol. 290, Iss. 4 American journal of physiology. Regulatory, integrative and comparative physiology, 2006. (DOI: 10.1152/ajpregu.00363.2005)
- Sun, H, Molacek, E, Zheng, H, Fang, Q, Patel, K P., and Mayhan, William. Alcohol-induced impairment of neuronal nitric oxide synthase (nNOS)-dependent dilation of cerebral arterioles: role of NAD(P)H oxidase., 321-8. Vol. 40, Iss. 2 Journal of molecular and cellular cardiology, 2006. (DOI: 10.1016/j.yjmcc.2005.11.004)
- Fang, Q, Sun, H, Arrick, Denise, and Mayhan, William. Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine., 631-6. Vol. 100, Iss. 2 Journal of applied physiology (Bethesda, Md. : 1985), 2006. (DOI: 10.1152/japplphysiol.00975.2005)
- Sun, H, Zheng, H, Molacek, E, Fang, Q, Patel, K P., and Mayhan, William. Role of NAD(P)H oxidase in alcohol-induced impairment of endothelial nitric oxide synthase-dependent dilation of cerebral arterioles., 495-500. Vol. 37, Iss. 2 Stroke, 2006. (DOI: 10.1161/01.STR.0000199033.06678.c3)
- Trickler, W J., Mayhan, William, and Miller, D W.. Brain microvessel endothelial cell responses to tumor necrosis factor-alpha involve a nuclear factor kappa B (NF-kappaB) signal transduction pathway., 24-31. Vol. 1048, Iss. 1-2 Brain research, 2005. (DOI: 10.1016/j.brainres.2005.04.028)
- Sun, H, and Mayhan, William. Sex difference in nitric oxide synthase-dependent dilatation of cerebral arterioles during long-term alcohol consumption., 430-6. Vol. 29, Iss. 3 Alcoholism, clinical and experimental research, 2005.
- Fang, Q, Sun, H, and Mayhan, William. L-arginine prevents impaired endothelium-dependent cerebral arteriolar dilatation during acute infusion of nicotine., 1009-14. Vol. 6, Iss. 6 Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2004.
- Mayhan, William, Mayhan, J F., Sun, H, and Patel, K P.. In vivo properties of potassium channels in cerebral blood vessels during diabetes mellitus., 605-13. Vol. 11, Iss. 7 Microcirculation (New York, N.Y. : 1994), 2004. (DOI: 10.1080/10739680490503410)
- Sun, H, Fang, Q, and Mayhan, William. Inward rectifier potassium channels in the basilar artery during chronic alcohol consumption., 1557-61. Vol. 28, Iss. 10 Alcoholism, clinical and experimental research, 2004.
- Yarnitsky, D, Gross, Y, Lorian, A, Shalev, A, Lamensdorf, I, Bornstein, R, Shorer, S, Mayevsky, A, Patel, K P., Abbott, N J., and Mayhan, William. Blood-brain barrier opened by stimulation of the parasympathetic sphenopalatine ganglion: a new method for macromolecule delivery to the brain., 303-9. Vol. 101, Iss. 2 Journal of neurosurgery, 2004. (DOI: 10.3171/jns.2004.101.2.0303)
- Mayhan, William, Sun, H, Mayhan, J F., and Patel, K P.. Influence of exercise on dilatation of the basilar artery during diabetes mellitus., 1730-7. Vol. 96, Iss. 5 Journal of applied physiology (Bethesda, Md. : 1985), 2004. (DOI: 10.1152/japplphysiol.01185.2003)
- Schwaninger, R M., Sun, H, and Mayhan, William. Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats., 3415-25. Vol. 73, Iss. 26 Life sciences, 2003.
- Trauernicht, A K., Sun, H, Patel, K P., and Mayhan, William. Enalapril prevents impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in diabetic rats., 2698-703. Vol. 34, Iss. 11 Stroke, 2003. (DOI: 10.1161/01.STR.0000092121.62649.DC)
- Li , Y F., Mayhan, William, and Patel, K P.. Role of the paraventricular nucleus in renal excretory responses to acute volume expansion: role of nitric oxide., H1738-46. Vol. 285, Iss. 4 American journal of physiology. Heart and circulatory physiology, 2003. (DOI: 10.1152/ajpheart.00727.2002)
- Fang, Q, Sun, H, and Mayhan, William. Impairment of nitric oxide synthase-dependent dilatation of cerebral arterioles during infusion of nicotine., H528-34. Vol. 284, Iss. 2 American journal of physiology. Heart and circulatory physiology, 2003. (DOI: 10.1152/ajpheart.00752.2002)
- Mayhan, William. Pial vessel permeability to tracers using cranial windows., 121-31. Vol. 89 Methods in molecular medicine, 2003. (DOI: 10.1385/1-59259-419-0:121)
- Zheng, H, Li , Y F., Weiss, M, Mayhan, William, and Patel, K P.. Neuronal expression of fos protein in the forebrain of diabetic rats., 268-75. Vol. 956, Iss. 2 Brain research, 2002.
- Mayhan, William, and Sharpe, G M.. Acute and chronic treatment with nicotine impairs reactivity of arterioles in response to activation of potassium channels., 695-703. Vol. 39, Iss. 5 Journal of cardiovascular pharmacology, 2002.
- Prall, A K., Longo, G M., Mayhan, William, Waltke, E A., Fleckten, B, Thompson, R W., and Baxter, B T.. Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice., 923-9. Vol. 35, Iss. 5 Journal of vascular surgery, 2002.
- Sun, H, Patel, K P., and Mayhan, William. Impairment of neuronal nitric oxide synthase-dependent dilation of cerebral arterioles during chronic alcohol consumption., 663-70. Vol. 26, Iss. 5 Alcoholism, clinical and experimental research, 2002.
- Mayhan, William, Sun, H, and Irvine, S D.. Influence of gender on dilatation of the basilar artery during diabetes mellitus., 182-90. Vol. 930, Iss. 1-2 Brain research, 2002.
- Mayhan, William. Cellular mechanisms by which tumor necrosis factor-alpha produces disruption of the blood-brain barrier., 144-52. Vol. 927, Iss. 2 Brain research, 2002.
- Li , Y F., Mayhan, William, and Patel, K P.. NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide., H2328-36. Vol. 281, Iss. 6 American journal of physiology. Heart and circulatory physiology, 2001.
- Sun, H, Patel, K P., and Mayhan, William. Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption., H1863-9. Vol. 281, Iss. 5 American journal of physiology. Heart and circulatory physiology, 2001.
- Mayhan, William, and Sharpe, G M.. Generation of superoxide anion impairs histamine-induced increases in macromolecular efflux., 275-81. Vol. 61, Iss. 3 Microvascular research, 2001. (DOI: 10.1006/mvre.2001.2313)
- Mayhan, William. Regulation of blood-brain barrier permeability., 89-104. Vol. 8, Iss. 2 Microcirculation (New York, N.Y. : 1994), 2001.
- Mayhan, William, Trauernicht, A K., and Irvine, S D.. Insulin reverses impaired acetylcholine-induced dilatation of the rat basilar artery during diabetes mellitus., 195-201. Vol. 893, Iss. 1-2 Brain research, 2001.
- Sun, H, and Mayhan, William. Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals., H992-H1001. Vol. 280, Iss. 3 American journal of physiology. Heart and circulatory physiology, 2001.
- Sun, H, and Mayhan, William. Superoxide dismutase ameliorates impaired nitric oxide synthase-dependent dilatation of the basilar artery during chronic alcohol consumption., 116-22. Vol. 891, Iss. 1-2 Brain research, 2001.
- Mayhan, William. Leukocyte adherence contributes to disruption of the blood-brain barrier during activation of mast cells., 112-20. Vol. 869, Iss. 1-2 Brain research, 2000.
- Mayhan, William. Nitric oxide donor-induced increase in permeability of the blood-brain barrier., 101-8. Vol. 866, Iss. 1-2 Brain research, 2000.
- Patel, K P., Zhang, K, Kenney, M J., Weiss, M, and Mayhan, William. Neuronal expression of Fos protein in the hypothalamus of rats with heart failure., 27-34. Vol. 865, Iss. 1 Brain research, 2000.
- Sato, J, Mohácsi, T, Noel, A, Jost, C, Gloviczki, P, Mozes, G, Katusic, Z S., O'Brien, T, and Mayhan, William. In vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits enhances endothelium-dependent relaxations., 968-75. Vol. 31, Iss. 4 Stroke, 2000.
- Mayhan, William. Inhibition of nitric oxide synthase does not alter basal permeability of the blood-brain barrier., 143-9. Vol. 855, Iss. 1 Brain research, 2000.
- Mayhan, William, and Sharpe, G M.. Aminoguanidine suppresses basal macromolecular extravasation during diabetes mellitus., 52-60. Vol. 59, Iss. 1 Microvascular research, 2000. (DOI: 10.1006/mvre.1999.2194)
- Mayhan, William, Irvine, S D., and Sharpe, G M.. Constrictor responses of resistance arterioles during diabetes mellitus., 147-56. Vol. 44, Iss. 3 Diabetes research and clinical practice, 1999.
- Mayhan, William. VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway., C1148-53. Vol. 276, Iss. 5 Pt 1 The American journal of physiology, 1999.
- Mayhan, William, and Sharpe, G M.. Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatation: effect of superoxide dismutase., 1126-34. Vol. 86, Iss. 4 Journal of applied physiology (Bethesda, Md. : 1985), 1999.
- Mayhan, William. Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch., 48-54. Vol. 133, Iss. 1 The Journal of laboratory and clinical medicine, 1999. (DOI: 10.1053/lc.1999.v133.a94238)
- Mayhan, William, Sharpe, G M., and Anding, P. Agonist-induced release of nitric oxide during acute exposure to nicotine., 1829-37. Vol. 65, Iss. 17 Life sciences, 1999.
- Ikenaga, H, Ishii, N, Didion, S P., Zhang, K, Cornish, K G., Patel, K P., Mayhan, William, and Carmines, P K.. Suppressed impact of nitric oxide on renal arteriolar function in rats with chronic heart failure., F79-87. Vol. 276, Iss. 1 Pt 2 The American journal of physiology, 1999.
- Mayhan, William, and Sharpe, G M.. Superoxide dismutase restores endothelium-dependent arteriolar dilatation during acute infusion of nicotine., 1292-8. Vol. 85, Iss. 4 Journal of applied physiology (Bethesda, Md. : 1985), 1998.
- Mayhan, William, and Patel, K P.. Treatment with dimethylthiourea prevents impaired dilatation of the basilar artery during diabetes mellitus., H1895-901. Vol. 274, Iss. 6 Pt 2 The American journal of physiology, 1998.
- Mayhan, William. Effect of lipopolysaccharide on the permeability and reactivity of the cerebral microcirculation: role of inducible nitric oxide synthase., 353-7. Vol. 792, Iss. 2 Brain research, 1998.
- Mayhan, William, and Sharpe, G M.. Nicotine impairs histamine-induced increases in macromolecular efflux: role of oxygen radicals., 1589-95. Vol. 84, Iss. 5 Journal of applied physiology (Bethesda, Md. : 1985), 1998.
- Mayhan, William. Constrictor responses of the rat basilar artery during diabetes mellitus., 326-31. Vol. 783, Iss. 2 Brain research, 1998.
- Mayhan, William, and Sharpe, G M.. Superoxide dismutase restores impaired histamine-induced increases in venular macromolecular efflux during diabetes mellitus., 211-8. Vol. 5, Iss. 2-3 Microcirculation (New York, N.Y. : 1994), 1998.
- Didion, S P., Carmines, P K., Ikenaga, H, and Mayhan, William. Enhanced constrictor responses of skeletal muscle arterioles during chronic myocardial infarction., H1502-8. Vol. 273, Iss. 3 Pt 2 The American journal of physiology, 1997.
- Zhang, K, Mayhan, William, and Patel, K P.. Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity., R864-72. Vol. 273, Iss. 3 Pt 2 The American journal of physiology, 1997.
- Mayhan, William. Superoxide dismutase partially restores impaired dilatation of the basilar artery during diabetes mellitus., 204-9. Vol. 760, Iss. 1-2 Brain research, 1997.
- Didion, S P., and Mayhan, William. Effect of chronic myocardial infarction on in vivo reactivity of skeletal muscle arterioles., H2403-8. Vol. 272, Iss. 5 Pt 2 The American journal of physiology, 1997.
- Mayhan, William, Patel, K P., and Sharpe, G M.. Effect of L-arginine on reactivity of hamster cheek pouch arterioles during diabetes mellitus., 107-12. Vol. 17, Iss. 3 International journal of microcirculation, clinical and experimental, 1997.
- Mayhan, William, and Patel, K P.. Effect of nicotine on endothelium-dependent arteriolar dilatation in vivo., H2337-42. Vol. 272, Iss. 5 Pt 2 The American journal of physiology, 1997.
- Mayhan, William. L-arginine does not reverse impaired agonist-induced increases in macromolecular efflux during diabetes mellitus., 215-22. Vol. 34, Iss. 1 Cardiovascular research, 1997.
- Patel, K P., Zhang, K, Hein, M, and Mayhan, William. Peripheral noradrenergic turnover in streptozotocin-induced diabetic rats., 1-9. Vol. 35, Iss. 1 Diabetes research and clinical practice, 1997.
- Mayhan, William. Role of nitric oxide in histamine-induced increases in permeability of the blood-brain barrier., 70-6. Vol. 743, Iss. 1-2 Brain research, 1996.
- Mayhan, William. Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension., 337-41. Vol. 738, Iss. 2 Brain research, 1996.
- Mayhan, William, and Sharpe, G M.. Effect of cigarette smoke extract on arteriolar dilatation in vivo., 1996-2003. Vol. 81, Iss. 5 Journal of applied physiology (Bethesda, Md. : 1985), 1996.
- Mayhan, William, and Didion, S P.. Effect of chronic alcohol consumption on responses of cerebral arterioles., 538-42. Vol. 20, Iss. 3 Alcoholism, clinical and experimental research, 1996.
- Mayhan, William, and Didion, S P.. Glutamate-induced disruption of the blood-brain barrier in rats. Role of nitric oxide., 965-9; discussion 970. Vol. 27, Iss. 5 Stroke, 1996.
- Mayhan, William, Didion, S P., and Patel, K P.. L-Arginine does not restore dilatation of the basilar artery during diabetes mellitus., 500-6. Vol. 16, Iss. 3 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996. (DOI: 10.1097/00004647-199605000-00017)
- Mayhan, William, and Didion, S P.. Acute effects of ethanol on responses of cerebral arterioles., 2097-101; discussion 2102. Vol. 26, Iss. 11 Stroke, 1995.
- Mayhan, William, and Didion, S P.. Activation of protein kinase C does not participate in disruption of the blood-brain barrier to albumin during acute hypertension., 106-12. Vol. 696, Iss. 1-2 Brain research, 1995.
- Mayhan, William, and Patel, K P.. Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C., H1297-302. Vol. 269, Iss. 4 Pt 2 The American journal of physiology, 1995.
- Patel, K P., Zhang, P L., and Mayhan, William. Blunting of renal excretory responses to acute volume expansion by nicotine: role of renal nerves., 1174-81. Vol. 274, Iss. 3 The Journal of pharmacology and experimental therapeutics, 1995.
- Mayhan, William. Role of nitric oxide in disruption of the blood-brain barrier during acute hypertension., 99-103. Vol. 686, Iss. 1 Brain research, 1995.
- Rubinstein, I, and Mayhan, William. L-arginine dilates cheek pouch arterioles in hamsters with hereditary cardiomyopathy but not in controls., 313-8. Vol. 125, Iss. 3 The Journal of laboratory and clinical medicine, 1995.
- Mayhan, William, and Rubinstein, I. Response of hamster cheek pouch microcirculation to endothelin and endothelin receptor antagonists., 48-52. Vol. 15, Iss. 1 International journal of microcirculation, clinical and experimental, 1995.
- Mayhan, William, and Rubinstein, I. Effects of endothelin receptor antagonists on bradykinin-induced increases in macromolecular efflux., 633-44. Vol. 18, Iss. 6 Inflammation, 1994.
- Mayhan, William. Effect of diabetes mellitus on responses of the rat basilar artery to activation of beta-adrenergic receptors., 208-12. Vol. 659, Iss. 1-2 Brain research, 1994.
- Mayhan, William. Nitric oxide accounts for histamine-induced increases in macromolecular extravasation., H2369-73. Vol. 266, Iss. 6 Pt 2 The American journal of physiology, 1994.
- Mayhan, William. Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels., 35-9. Vol. 636, Iss. 1 Brain research, 1994.
- Mayhan, William. Responses of cerebral arterioles to activation of beta-adrenergic receptors during diabetes mellitus., 141-6. Vol. 25, Iss. 1 Stroke, 1994.
- Mayhan, William. In vivo reactivity of resistance arterioles to activation of ATP-sensitive K+ channels., 109-12. Vol. 242, Iss. 1 European journal of pharmacology, 1993.
- Mayhan, William, and Rubinstein, I. Cigarette smoke extract potentiates bradykinin-induced increases in microvascular permeability., 27-32. Vol. 75, Iss. 1 Journal of applied physiology (Bethesda, Md. : 1985), 1993.
- Mayhan, William, and Faraci, F M.. Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels., H152-7. Vol. 265, Iss. 1 Pt 2 The American journal of physiology, 1993.
- Mayhan, William. Role of nitric oxide in leukotriene C4-induced increases in microvascular transport., H409-14. Vol. 265, Iss. 1 Pt 2 The American journal of physiology, 1993.
- Gao, X P., Mayhan, William, Conlon, J M., Rennard, S I., and Rubinstein, I. Mechanisms of T-kinin-induced increases in macromolecule extravasation in vivo., 2896-903. Vol. 74, Iss. 6 Journal of applied physiology (Bethesda, Md. : 1985), 1993.
- Mayhan, William. Cerebral circulation during diabetes mellitus., 377-91. Vol. 57, Iss. 2-3 Pharmacology & therapeutics, 1993.
- Yong, T, Gilmore, J P., Joyner, W L., and Mayhan, William. In vivo responses of allografted cerebral parenchymal arterioles to ethanol and angiotensin II: effect of calcium channel blockade., 417-24. Vol. 11, Iss. 4 International journal of microcirculation, clinical and experimental, 1992.
- Mayhan, William. Effect of diabetes mellitus on responses of the basilar artery in rats to products released by platelets., 1499-503. Vol. 23, Iss. 10 Stroke, 1992.
- Mayhan, William. Endothelium-dependent responses of cerebral arterioles to adenosine 5'-diphosphate., 353-8. Vol. 29, Iss. 5 Journal of vascular research, 1992.
- Mayhan, William. Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5'-diphosphate and bradykinin., 295-305. Vol. 16, Iss. 4 Inflammation, 1992.
- Mayhan, William, and Rubinstein, I. Acetylcholine induces vasoconstriction in the microcirculation of cardiomyopathic hamsters: reversal by L-arginine., 1372-7. Vol. 184, Iss. 3 Biochemical and biophysical research communications, 1992.
- Mayhan, William. Impairment of endothelium-dependent dilatation of the basilar artery during diabetes mellitus., 297-302. Vol. 580, Iss. 1-2 Brain research, 1992.
- Yong, T, Gao, X P., Koizumi, S, Conlon, J M., Rennard, S I., Mayhan, William, and Rubinstein, I. Role of peptidases in bradykinin-induced increase in vascular permeability in vivo., 952-9. Vol. 70, Iss. 5 Circulation research, 1992.
- Yong, T, and Mayhan, William. Effect of prostaglandin E1 on leukotriene C4-induced increases in vascular permeability of hamster cheek pouch., 159-67. Vol. 16, Iss. 2 Inflammation, 1992.
- Mayhan, William. Responses of cerebral arterioles during chronic ethanol exposure., H787-91. Vol. 262, Iss. 3 Pt 2 The American journal of physiology, 1992.
- Mayhan, William. Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension., H539-43. Vol. 262, Iss. 2 Pt 2 The American journal of physiology, 1992.
- Rubenstein, I, Yong, T, Rennard, S I., and Mayhan, William. Cigarette smoke extract attenuates endothelium-dependent arteriolar dilatation in vivo., H1913-8. Vol. 261, Iss. 6 Pt 2 The American journal of physiology, 1991.
- Yang, S T., Mayhan, William, Faraci, F M., and Heistad, D D.. Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats., 1177-82. Vol. 22, Iss. 9 Stroke, 1991.
- Mayhan, William. Disruption of the blood-brain barrier in open and closed cranial window preparations in rats., 1059-63. Vol. 22, Iss. 8 Stroke, 1991.
- Yang, S T., Mayhan, William, Faraci, F M., and Heistad, D D.. Endothelium-dependent responses of cerebral blood vessels during chronic hypertension., 612-8. Vol. 17, Iss. 5 Hypertension (Dallas, Tex. : 1979), 1991.
- Murray, M A., Heistad, D D., and Mayhan, William. Role of protein kinase C in bradykinin-induced increases in microvascular permeability., 1340-8. Vol. 68, Iss. 5 Circulation research, 1991.
- Mayhan, William. Responses of the basilar artery to products released by platelets during chronic hypertension., 97-102. Vol. 545, Iss. 1-2 Brain research, 1991.
- Mayhan, William, Simmons, L K., and Sharpe, G M.. Mechanism of impaired responses of cerebral arterioles during diabetes mellitus., H319-26. Vol. 260, Iss. 2 Pt 2 The American journal of physiology, 1991.
- Faraci, F M., Mayhan, William, and Heistad, D D.. Responses of rat basilar artery to acetylcholine and platelet products in vivo., 56-60. Vol. 22, Iss. 1 Stroke, 1991.
- Mayhan, William. Effect of diabetes mellitus on disruption of the blood-brain barrier during acute hypertension., 106-10. Vol. 534, Iss. 1-2 Brain research, 1990.
- Mayhan, William. Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension., H1455-62. Vol. 259, Iss. 5 Pt 2 The American journal of physiology, 1990.
- Faraci, F M., Mayhan, William, and Heistad, D D.. Vascular effects of acetazolamide on the choroid plexus., 23-7. Vol. 254, Iss. 1 The Journal of pharmacology and experimental therapeutics, 1990.
- Mayhan, William, and Faraci, F M.. Cerebral vasoconstrictor responses to serotonin during chronic hypertension., 872-6. Vol. 15, Iss. 6 Pt 2 Hypertension (Dallas, Tex. : 1979), 1990.
- Mayhan, William. Disruption of blood-brain barrier during acute hypertension in adult and aged rats., H1735-8. Vol. 258, Iss. 6 Pt 2 The American journal of physiology, 1990.
- Mayhan, William, Faraci, F M., Baumbach, G L., and Heistad, D D.. Effects of aging on responses of cerebral arterioles., H1138-43. Vol. 258, Iss. 4 Pt 2 The American journal of physiology, 1990.
- Faraci, F M., Mayhan, William, and Heistad, D D.. Effect of vasopressin on production of cerebrospinal fluid: possible role of vasopressin (V1)-receptors., R94-8. Vol. 258, Iss. 1 Pt 2 The American journal of physiology, 1990.
- Heistad, D D., Mayhan, William, Coyle, P, and Baumbach, G L.. Impaired dilatation of cerebral arterioles in chronic hypertension., 258-62. Vol. 27, Iss. 2-5 Blood vessels, 1990.
- Mayhan, William, Faraci, F M., Spector, R, and Heistad, D D.. Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus., H834-8. Vol. 257, Iss. 3 Pt 2 The American journal of physiology, 1989.
- Faraci, F M., Choi, J, Baumbach, G L., Mayhan, William, and Heistad, D D.. Microcirculation of the area postrema. Permeability and vascular responses., 417-25. Vol. 65, Iss. 2 Circulation research, 1989.
- Mayhan, William, Faraci, F M., Siems, J L., and Heistad, D D.. Role of molecular charge in disruption of the blood-brain barrier during acute hypertension., 658-64. Vol. 64, Iss. 4 Circulation research, 1989.
- Mayhan, William. Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus., H621-5. Vol. 256, Iss. 3 Pt 2 The American journal of physiology, 1989.
- Faraci, F M., Mayhan, William, and Heistad, D D.. Effect of serotonin on blood flow to the choroid plexus., 121-6. Vol. 478, Iss. 1 Brain research, 1989.
- Mayhan, William, Baumbach, G L., and Heistad, D D.. Mechanisms and implications of cerebral vasoconstriction in chronic hypertension., 1-6. Vol. 102 Transactions of the Association of American Physicians, 1989.
- Mayhan, William, Faraci, F M., and Heistad, D D.. Responses of cerebral arterioles to adenosine 5'-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension., 556-61. Vol. 12, Iss. 6 Hypertension (Dallas, Tex. : 1979), 1988.
- Mayhan, William, Amundsen, S M., Faraci, F M., and Heistad, D D.. Responses of cerebral arteries after ischemia and reperfusion in cats., H879-84. Vol. 255, Iss. 4 Pt 2 The American journal of physiology, 1988.
- Faraci, F M., Mayhan, William, Farrell, W J., and Heistad, D D.. Humoral regulation of blood flow to choroid plexus: role of arginine vasopressin., 373-9. Vol. 63, Iss. 2 Circulation research, 1988.
- Faraci, F M., Mayhan, William, Schmid, P G., and Heistad, D D.. Effects of arginine vasopressin on cerebral microvascular pressure., H70-6. Vol. 255, Iss. 1 Pt 2 The American journal of physiology, 1988.
- Mayhan, William, Faraci, F M., and Heistad, D D.. Effects of vasodilatation and acidosis on the blood-brain barrier., 179-92. Vol. 35, Iss. 2 Microvascular research, 1988.
- Faraci, F M., Mayhan, William, Williams, J K., and Heistad, D D.. Effects of vasoactive stimuli on blood flow to choroid plexus., H286-91. Vol. 254, Iss. 2 Pt 2 The American journal of physiology, 1988.
- Mayhan, William, Faraci, F M., and Heistad, D D.. Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension., H1435-40. Vol. 253, Iss. 6 Pt 2 The American journal of physiology, 1987.
- Faraci, F M., Mayhan, William, Werber, A H., and Heistad, D D.. Cerebral circulation: effects of sympathetic nerves and protective mechanisms during hypertension., II102-6. Vol. 61, Iss. 5 Pt 2 Circulation research, 1987.
- Mayhan, William, Faraci, F M., and Heistad, D D.. Mechanisms of protection of the blood-brain barrier during acute hypertension in chronically hypertensive rats., III101-5. Vol. 9, Iss. 6 Pt 2 Hypertension (Dallas, Tex. : 1979), 1987.
- Faraci, F M., Heistad, D D., and Mayhan, William. Role of large arteries in regulation of blood flow to brain stem in cats., 115-23. Vol. 387 The Journal of physiology, 1987.
- Faraci, F M., Mayhan, William, and Heistad, D D.. Segmental vascular responses to acute hypertension in cerebrum and brain stem., H738-42. Vol. 252, Iss. 4 Pt 2 The American journal of physiology, 1987.
- Mayhan, William, Werber, A H., and Heistad, D D.. Protection of cerebral vessels by sympathetic nerves and vascular hypertrophy., I107-12. Vol. 75, Iss. 1 Pt 2 Circulation, 1987.
- Mayhan, William, Faraci, F M., and Heistad, D D.. Disruption of the blood-brain barrier in cerebrum and brain stem during acute hypertension., H1171-5. Vol. 251, Iss. 6 Pt 2 The American journal of physiology, 1986.
- Mayhan, William, Sahagun, G, Spector, R, and Heistad, D D.. Effects of leukotriene C4 on the cerebral microvasculature., H471-4. Vol. 251, Iss. 2 Pt 2 The American journal of physiology, 1986.
- Baumbach, G L., Mayhan, William, and Heistad, D D.. Protection of the blood-brain barrier by hypercapnia during acute hypertension., H282-7. Vol. 251, Iss. 2 Pt 2 The American journal of physiology, 1986.
- Mayhan, William, and Heistad, D D.. Role of veins and cerebral venous pressure in disruption of the blood-brain barrier., 216-20. Vol. 59, Iss. 2 Circulation research, 1986.
- Mayhan, William, and Heistad, D D.. Effect of flordipine on cerebral blood flow., 92-7. Vol. 235, Iss. 1 The Journal of pharmacology and experimental therapeutics, 1985.
- Mayhan, William, and Heistad, D D.. Permeability of blood-brain barrier to various sized molecules., H712-8. Vol. 248, Iss. 5 Pt 2 The American journal of physiology, 1985.
- Mayhan, William, and Joyner, W L.. The effect of altering the external calcium concentration and a calcium channel blocker, verapamil, on microvascular leaky sites and dextran clearance in the hamster cheek pouch., 159-79. Vol. 28, Iss. 2 Microvascular research, 1984.
- Joyner, W L., Mayhan, William, Johnson, R L., and Phares, C K.. Microvascular alterations develop in Syrian hamsters after the induction of diabetes mellitus by streptozotocin., 93-100. Vol. 30, Iss. 2 Diabetes, 1981.