The Roux lab investigates the structure and function of the mammalian nuclear envelope in health and disease. We have identified and are functionally characterizing several novel members of the LINC-complex. These proteins are retained on the outer nuclear membrane where they appear to perform specific roles in specialized cell types. We are also investigating the mechanisms by which defects in a single constituent of the nuclear lamina, the intermediate filament scaffold inside the nucleus, lead to a wide variety of diseases called laminopathies. These studies are supported by the BioID method to screen for interacting and proximate proteins.